PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL

十年间核密度的变化

• 批准号: 6446369
• 负责人: BARBARA EDEN KLEIN
• 金额: $ 6.26万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6446369
• 关键词: aging; biomedical automation; cataract; clinical research; computer assisted medical decision making; cornea opacity; densitometry; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder classification; disease /disorder proneness /risk; eye disorder diagnosis; gender difference; human data; image processing; longitudinal human study; pathologic process

DESCRIPTION: (Applicant's Abstract) Nuclear sclerosis, and its clinically important manifestation as nuclear cataract, is a common age-related ocular problem. In Beaver Dam, Wisconsin, nuclear cataract was the most common cataract type to precede lens extraction While older age and female gender are associated with increased risk, other factors have been found and still other, hypothesized to also be associated with risk, some positively and others negatively. Many current epidemiologic studies of nuclear sclerosis use slit lamp photographs to document severity and compare these with photographic standards to assign severity levels. The resultant grades, while in general ordered as to severity, are variable regarding repeat masked gradings by the same and by different graders. Thus, effects of risk or protective factor, which may be small to moderate, may be missed. We have developed a semi-automated scheme for measuring nuclear density, a reflection of nuclear sclerosis, from previously collected photographs. The method reflects current manual grading schemes in ordering severity, but is highly reproducible. We propose to apply these methods to slit lamp photographs taken three times over a ten-year interval in the large cohort participating in the Beaver Dam Eye Study. This will permit quantitation of nuclear sclerosis in a more reliable manner and on a finer scale than with current manual grading. We propose to examine relationships between previously hypothesized risk and protective factors for prevalent severity of nuclear sclerosis at baseline and for its progression, and to estimate the association of nuclear density with measures of visual function. The advantages of developing and testing these procedures in the Beaver Dam Eye Study are that (1) the data are from a free-living, unselected population in which the spectrum nuclear sclerosis is likely to represent that in other similar communities and (2) the photographs are in hand and thus the project is economical. The approach described will be important in clinical trials that are ongoing, others that have been completed, and still others that are planned by the National Eye Institute and other groups in which finding small to moderate affects will be enhanced by more reliable measures of disease.

描述：（申请人的摘要）核硬化症及其在临床上 重要的表现为核白内障，是一种常见的年龄相关眼 问题。在威斯康星州的海狸大坝中，核白内障是最常见的 白内障类型是在年龄和女性的镜头提取之前提取镜头的 与风险增加相关，发现了其他因素，还有其他因素， 假设也与风险相关，有些是积极的 负面。当前许多核硬化症使用狭缝的流行病学研究 灯照片记录严重性并将其与照片进行比较 分配严重程度的标准。最终成绩，一般而言 关于严重程度的订购，对于重复掩盖的等级是可变的 相同的和不同的级别的人。因此，风险或保护因素的影响， 可能很小至中等，可能会错过。我们已经开发了 测量核密度的半自动化方案，反射核 硬化，从先前收集的照片中。该方法反映了当前 手动分级方案以订购严重性，但高度可重复。我们 建议将这些方法应用于剪灯照片的剪裁照片三次 大型队列参加了Beaver Dam Eye的十年间隔 学习。这将允许在更可靠的 与当前的手动分级相比，态度和规模更细。我们建议 检查以前假设的风险与保护性之间的关系 基线及其核硬化症严重程度普遍的因素 进展，并估算核密度与度量的关联 视觉功能。制定和测试这些程序的优点 在Beaver Dam的眼睛研究中，（1）数据来自自由生活， 频谱核硬化的未选择人口 表示在其他类似社区和（2）照片中 因此，该项目是经济的。所描述的方法在 正在进行的临床试验，其他已经完成的临床试验，仍然 其他由国家眼科研究所和其他团体计划的 通过更可靠的措施，寻找小到中等影响的影响将增强 疾病。