Family Clustering of Incidence & Progression of Cataract

发病率的家庭聚集性

• 批准号: 6322703
• 负责人: BARBARA EDEN KLEIN
• 金额: $ 14.55万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6322703
• 关键词: aging; biotechnology; cataract; clinical research; computer data analysis; eye disorder; family genetics; genetic susceptibility; human data; human morbidity; human mortality; interview; intraocular pressure; linkage mapping; longitudinal human study; pathologic process

DESCRIPTION: (Applicant's Abstract) This proposal describes a population-based cohort study aimed at describing the family aggregation of age-related cataracts, visual function, intra-ocular pressure, and systemic characteristics of aging, cross-sectionally and longitudinally The population resides in Beaver Dam, Wisconsin. Subjects were 43-86 years of age at the first examination in 1988-90 Standardized protocols for interviews, examination, blood tests, and ocular photography and grading were performed at first examination and two follow-up examinations in 1993-95 and 1998-2000. Within the baseline population (n equals 4,926) we identified 587 sibling groups composed of 1,403 persons. Study participants have had standardized examinations at the three examination cycles. Information has been collected regarding cataract, other age-related eye diseases, medical conditions, medication usage; blood pressures, height and weight have been measured, as have several blood parameters baseline. At the follow-up visits, other measures of frailty (estimated by hand grip strength, slower timed walk, decrease peak expiratory flow) have been added to the protocol. Mortality has been carefully monitored and death certificate information has been obtained. We will investigate whether changes in cataract, as well as other ocular and systemic factors, aggregate in families and whether families that display greater progression of cataracts are at greater risk of systemic morbidity, frailty and mortali1y. During the course of the study, we have had follow-up interviews during which we have become aware of about 400 avuncular, parent and cousin relations in the community. We will complete our family pedigree information prior to the beginning of this grant. We propose extensive family aggregation analyses using generalized estimating equations and, when appropriate, commingling and segregation analyses. This grant will capitalize on data previously collected from grants funded by the National Eye Institute. We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework.

描述：（申请人的摘要）该提案描述了一项基于人群的队列研究，旨在描述与年龄有关的家庭聚集 白内障，视觉功能，眼内压力和全身特征 衰老，横截面和纵向的人口位于海狸中 威斯康星州大坝。受试者在第一次考试中为43-86岁 1988 - 90年的访谈，检查，血液检查和 首次检查时进行了眼摄影和分级 1993 - 95年和1998 - 2000年的后续考试。基线人口 （n等于4,926）我们确定了587个由1,403人组成的同胞组。 研究参与者在三个考试中进行了标准化考试 周期。已经收集了有关白内障，其他与年龄有关的眼部疾病，医疗状况，药物使用情况的信息；血压，身高和 重量已经测量，几个血参数基线也是如此。在 后续访问，其他脆弱的措施（通过手握力估计， 定时步行较慢，降低峰值呼气流）已添加到 协议。死亡率已仔细监测和死亡证明 已获得信息。我们将调查白内障的变化是否 以及其他眼和全身因素，家庭中的总和以及是否 表现出更大白内障进展的家庭面临着更大的风险 系统性发病率，脆弱和凡人。 在研究过程中，我们进行了后续采访。 我们已经意识到大约有400个Avuncular，父母和堂兄关系 社区。我们将在完成之前完成家庭谱系信息 这笔赠款的开始。我们建议使用大量的家庭聚合分析 广义估计方程式，并在适当的时候进行混合和 隔离分析。该赠款将利用先前收集的数据 来自国家眼科研究所资助的赠款。我们目前没有资金 支持提议的分析。我们相信这个项目提供了可能性 在大量家庭中检查重要假设 基于人群的框架。