STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS

弱视和斜视的结构基础

• 批准号: 6384375
• 负责人: JONATHAN C HORTON
• 金额: $ 38.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6384375
• 关键词: Macaca mulatta; Saimiri; age difference; amblyopia; autoradiography; binocular vision; brain mapping; electrophysiology; eye coordination disorder; functional magnetic resonance imaging; histochemistry /cytochemistry; human tissue; microinjections; neural plasticity; neuroanatomy; pathologic process; structural biology; visual cortex; visual deprivation; visual fields

The primary goal of this project is to uncover physiological and anatomical correlates of amblyopia in both humans and monkeys. This will continue the P.I.'s previous grant concerning the structure of ocular dominance columns (ODC) in animals and humans. There are 5 new specific aims that he will investigate: (1) The effect of strabismus on periodicity of ocular dominance columns, (2) Possible disruption of intrinsic connections from layer 4C to layer 3 in V1, (3) Alterations in human amblyopes of the complete pattern of ODC's, the organization of CO stripes in V2, and the organization of other extrastriate visual areas, (4) the cortical locus of visual suppression in strabismus and (5) the identity of a visual area anterior to macaque dorsal V2 that contains a unique CO pattern. Together, these new experiments will extend the previous work by investigating mechanisms beyond the ODC's that might be responsible for the poor vision in amblyopia.

该项目的主要目标是发现生理和 人类和猴子的弱视的解剖学相关。这会 继续P.I.先前关于眼睛结构的赠款 动物和人类的优势柱（ODC）。 有5个新的特定 他将调查的目的：（1）斜视的影响 眼优势柱的周期性，（2）可能破坏 从第4C层到V1中的第3层的固有连接，（3）变化 在ODC的完整模式的人类弱视中 V2中的CO条纹以及其他外部视觉的组织 区域，（4）斜视和视觉抑制的皮质座位 （5）猕猴背V2的视觉区域的身份 包含独特的CO模式。 这些新实验将在一起 通过调查ODC之外的机制来扩展先前的工作 这可能是弱视的视力不佳的原因。