Functional Organization of Visual Area MT

视觉区域 MT 的功能组织

• 批准号: 6326498
• 负责人: RICHARD T BORN
• 金额: $ 34.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6326498
• 关键词: Aotus; Macaca; behavioral /social science research tag; binocular vision; brain electrical activity; brain mapping; electrostimulus; eye movements; microelectrodes; motion perception; neural information processing; neurons; psychophysics; single cell analysis; synapses; visual cortex; visual fields; visual perception; visual stimulus

DESCRIPTION(adapted from applicant's abstract): Since its discovery in the early 1970's, the middle temporal visual area (MT) of the primate has served as a valuable model of cortical sensory processing. Much is known about its basic receptive field properties. its connections, and its involvement in a number of important perceptual and behavioral functions. A rich body of literature exists describing interesting and important receptive field properties: selectivity for direction, speed. and binocular disparity and, very importantly, the existence of surrounds that are often selective for the same parameters and that render the neurons more selective for discontinuities in the visual world. The central goals of this application will be to understand the mechanisms underlying center-surround interactions in MT and the role that center-surround interactions play in perception and visually guided behavior. To study receptive field mechanisms, we will first examine in detail the space-time receptive field maps of MT neurons in alert monkeys. To learn more about the contributions of local circuitry to receptive field properties, we will study the intrinsic connections of MT with respect to functional maps of direction, binocular disparity, and center-surround interactions. We will also study the role of feedback connections in shaping the response properties of MT neurons by reversibly inactivating cortical regions that are reciprocally connected with MT. Finally, we will combine neuronal recordings, quantitative psychophysics, and microstimulation to study the role that neurons with center-surround receptive fields play in the spatial properties of motion perception. The overall product of the experiments detailed in this proposal will be a better understanding of the role that various sources of information play in shaping the response properties of neurons in MT and insights into the mechanisms by which MT receptive fields are constructed. We will also learn more about the hypothesized relationship between center-surround processing and the spatial properties of motion perception, including the important function of figure-ground segregation based on motion cues.

描述（改编自申请人的摘要）：自从其在 1970年代初，灵长类动物的中间时间视觉区域（MT）已成为 皮质感觉处理的宝贵模型。关于其基本知识知之甚少 接受场特性。它的联系及其参与了许多 重要的感知和行为功能。存在丰富的文学体系 描述有趣而重要的接受场特性：选择性 为了方向，速度。和双眼差异，非常重要的是 存在通常对相同参数选择性的环境的存在，并且 这使神经元在视觉世界中的不连续性更具选择性。 该应用程序的核心目标是了解机制 MT中的基础中心旋转相互作用以及中心周围的作用 互动在感知和视觉指导行为中发挥作用。 为了研究接受现场机制，我们将首先详细研究 警报猴子中MT神经元的时空接受场图。了解更多 关于局部电路对接收场特性的贡献，我们 将研究MT相对于功能图的固有连接 方向，双眼差异和中心旋转相互作用。我们也会 研究反馈连接在塑造MT响应特性中的作用 神经元通过不可逆转地灭活的皮质区域 与MT相连。最后，我们将结合神经元记录，定量 心理物理学和微刺激研究神经元与 中心旋转的接收场在运动的空间特性中发挥作用 洞察力。 本提案中详细介绍的实验的总体产品将是 更好地理解各种信息来源在 塑造神经元在MT中的响应特性以及对 建造MT接受场的机制。我们还将学习 有关中心旋转处理与 运动感知的空间特性，包括重要功能 基于运动提示的图形隔离。