NATIONAL DRUG ABUSE TREATMENT CLINICAL TRIALS NETWORK

国家药物滥用治疗临床试验网络

• 批准号: 6286935
• 负责人: Robert L. Hubbard
• 金额: $ 220万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-10 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6286935
• 关键词: adolescence (12-20); clinical research; clinical trials; cognitive behavior therapy; cooperative study; data management; deprenyl; drug abuse chemotherapy; drug abuse therapy; experimental designs; human subject; human therapy evaluation

DESCRIPTION: (Applicant's Abstract) This is the first resubmission of a proposal to establish a Southeastern Duke Node in the NIDA National Drug Abuse Clinical Trials Network. We will partner with at least 10 real world community-based treatment programs (CTPs). The CTPs reflect diverse demographics; several are in rural or small town settings. CTPs will not only implement existing research protocols but will collaborate with Node scientists to develop new research concepts. The coordination of the CTPs and the interface with other Nodes and NIDA will be directed by a Regional Research and Training Center (RRTC) that represents a confederation of investigators, trainers and research monitors from Duke University Medical Center (DUMC) Department of Psychiatry, the Duke Clinical Research Institute (DCRI), and the National Development and Research Institutes (NDRI) each with their own strengths and a history of collaborating with each other. The RRTC will maintain the clinical infrastructure and the research infrastructure and will be responsible for all aspects of conducting clinical trials. Concept research proposals that can utilize the unique scope of the CTN are delineated: 1) Multi-modal CBT for adolescent substance abusers with internalizing disorders and 2) Selegiline/CBT for cocaine dependence. To enhance our contribution to the CTN's focus on multi-center, effectiveness research designs, we have designated Dr. Robert Hubbard as PI and added a cadre of DUMC-DCRI experts on effectiveness research who will broaden the inclusiveness, generalizability and usefulness of our studies.

描述：（申请人的摘要）这是在NIDA国家药物滥用临床试验网络中建立东南公爵节点的提案的第一次重新提议。我们将与至少10个现实的基于社区的治疗计划（CTP）合作。 CTP反映了各种各样的人口统计学；有几个在农村或小镇环境中。 CTP不仅将实施现有的研究协议，而且将与节点科学家合作开发新的研究概念。 CTPS的协调以及与其他节点和NIDA的界面将由区域研究与培训中心（RRTC）指导，该中心代表了杜克大学医学中心（DUMC）精神病学系的研究人员，培训师和研究监测员的同盟，杜克临床研究所（DCRI）以及各自的研究所（DCRI），以及各自的研究所（DCRI），以及各自的经验（DRI），以及一名自身的历史（ndri and Drii）（他们的经验）（ 其他。 RRTC将维持临床基础设施和研究基础设施，并将负责进行临床试验的各个方面。概念研究建议可以使用CTN的独特范围：1）具有内在疾病的青少年滥用者的多模式CBT和2）可卡因依赖性的Selegiline/CBT。为了增强我们对CTN对多中心，有效性研究设计的贡献，我们将Robert Hubbard博士指定为PI，并在有效性研究上增加了DUMC-DCRI专家的干部，该研究将扩大我们研究的包容性，可普遍性和实用性。