Educational Attainment in Sickle Cell Disease

镰状细胞病的教育程度

• 批准号: 7136621
• 负责人: Allison A King
• 金额: $ 12.98万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-26 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7136621
• 关键词: academic achievement; adolescence (12-20); blood transfusion; clinical research; clinical trials; cognition disorders; congenital blood protein disorder; education evaluation /planning; human subject; human therapy evaluation; longitudinal human study; low socioeconomic status; magnetic resonance imaging; memory disorders; middle childhood (6-11); neuropsychological tests; patient oriented research; remedial /special education; sickle cell anemia; socioeconomics; stroke; training

DESCRIPTION (provided by applicant): The purpose of this proposal is to support the applicant in becoming an independent clinical investigator with expertise in improving educational attainment in children with sickle cell disease (SCD). The applicant will collaborate with her mentor and the multi-disciplinary SCD stroke research team at Washington University School of Medicine. The SCD stroke research team coordinates the 24 site multi-center Silent Infarct Transfusion Trial (SITT), and the applicant is the local principal investigator. She will gain experience with both her existing independent pilot trial and her investigator-initiated ancillary studies to SITT. These activities will provide a rich environment for conducting patient-oriented research and developing the skills for independent clinical investigation. Cognitive deficits and poor academic attainment are major barriers to independence in students with SCD. Over 40% of students with SCD will fail a grade or receive special education, and approximately 15% will graduate from high school in four years. This proposal will include three studies. The first study will expand her pilot trial for education rehabilitation in students with SCD and strokes to include students with SCD and significant memory deficits (> 1 SD below the age expected mean)(n=30). Each student will be randomized to receive two years of either tutoring or tutoring plus memory training skills to test the following hypothesis: An education rehabilitation program for students SCD and cognitive deficits is feasible, measured by > 80% of the students completing the program. A secondary analysis will be performed to determine the efficacy of the rehabilitation program on memory measures. The applicant has initiated two ancillary studies in SITT. The following hypothesis will be tested in students with sickle cell anemia (SCA) screened for silent cerebral infarcts: In students with SCA, a lower SES will result in a lower educational attainment than students with a high SES and SCA. The second ancillary study will test the following hypothesis in students with SCA who are randomized to either transfusion therapy or observation for three years: Students with SCA and silent strokes who receive blood transfusion therapy will have an improvement in their academic achievement when compared to students with silent strokes who are not transfused. The knowledge and skills acquired from completing these studies will allow the applicant to develop evidence based strategies to improve educational attainment in students with SCD.

描述（由申请人提供）： 该提案的目的是支持申请人成为一名独立的临床研究者，具有提高镰状细胞病（SCD）儿童受教育程度的专业知识。申请人将与其导师以及华盛顿大学医学院的多学科 SCD 中风研究团队合作。 SCD脑卒中研究团队协调24个地点的多中心无症状梗死输血试验（SITT），申请人为当地主要研究者。她将从现有的独立试点试验和研究者发起的 SITT 辅助研究中获得经验。这些活动将为开展以患者为中心的研究和培养独立临床研究的技能提供丰富的环境。认知缺陷和学业成绩差是患有 SCD 的学生独立的主要障碍。超过 40% 的患有 SCD 的学生会不及格或接受特殊教育，大约 15% 的学生会在四年内从高中毕业。该提案将包括三项研究。第一项研究将扩大她对患有 SCD 和中风的学生进行教育康复的试点试验，以包括患有 SCD 和显着记忆缺陷（比预期平均年龄低 1 个 SD）的学生 (n=30)。每个学生将被随机接受两年的辅导或辅导加记忆训练技能，以检验以下假设：针对学生 SCD 和认知缺陷的教育康复计划是可行的，根据超过 80% 的完成该计划的学生来衡量。将进行二次分析以确定康复计划对记忆测量的功效。申请人已在 SITT 中启动了两项辅助研究。以下假设将在筛查无症状脑梗塞的镰状细胞性贫血 (SCA) 学生中进行检验：在患有 SCA 的学生中，较低的 SES 会导致比具有较高 SES 和 SCA 的学生较低的教育程度。第二项辅助研究将在患有 SCA 的学生中检验以下假设，这些学生被随机接受输血治疗或观察三年：患有 SCA 和无症状中风的学生接受输血治疗后，其学业成绩将比患有 SCA 的学生有所提高。无声中风者，未输血。通过完成这些研究获得的知识和技能将使申请人能够制定基于证据的策略，以提高患有 SCD 的学生的教育程度。