Atypical Bacterial Infection as an Asthma Risk Factor

非典型细菌感染是哮喘的危险因素

• 批准号: 6536649
• 负责人: EVERETT RAND SUTHERLAND
• 金额: $ 12.01万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6536649
• 关键词: asthma; chlamydial disease; disease /disorder proneness /risk; human subject; mycoplasmal pneumonia; pathologic process; patient oriented research; questionnaires; respiratory disorder epidemiology; respiratory infections

DESCRIPTION (provided by applicant) Asthma, an inflammatory lung disease which causes chronic airflow obstruction, has a significant impact on the public health. There is mounting evidence that, in a subset of patients, pulmonary infection with mycoplasma and chlamydia is associated with chronic asthma. This study is designed to test the hypothesis that chronic infection with Mycoplasma pneumoniae or Chlamydia pneumoniae species is a risk factor for the development or worsening of asthma. A cohort of subjects with a history of clinically- and radiographically- evident M. pneumoniae and C. pneumoniae infection approximately nine years ago has been identified. All subjects in this cohort were tested for active mycoplasma or chlamydia infection with culture and polymerase chain reaction analysis of respiratory tract secretions, as well as serology. These patients will be studied using a respiratory symptoms questionnaire to determine the prevalence of asthma in this cohort nine years after the exposure. Following the questionnaire component of this study, additional testing will be performed on a subset of the cohort to further describe the clinical, physiologic, inflammatory and microbiologic characteristics of these patients. This series of investigations is designed to identify the importance of atypical bacterial infection to the development and clinical phenotype of asthma. An understanding of the association between mycoplasma and chlamydia species and asthma is critical to furthering our knowledge of asthma pathogenesis and provides the foundation on which interventions aimed at primary prevention may be based. The identification of infection as a risk factor for chronic asthma would be a significant advance in our ability to predict which patients have an increased likelihood of developing asthma and would facilitate the design and implementation of targeted attempts to reduce asthma incidence. The investigations described herein will be conducted as part of a comprehensive career development program in the methods of patient-oriented research. With this award, the candidate will become educated in the methods of patient-oriented research as part of a Master in Public Health degree program at the Harvard School of Public Health and will then apply the skills learned in the didactic setting to the implementation of this research protocol. The candidate is intent upon using this award to support a career development program that will ensure his success as an academic physician-scientist with a focus on patient-oriented research in diseases of the lungs.

描述（由申请人提供） 哮喘是一种导致慢性气流阻塞的炎症性肺部疾病， 对公众健康有重大影响。有越来越多的证据 在一部分患者中，肺部感染支原体和 衣原体与慢性哮喘有关。本研究旨在测试 肺炎支原体或衣原体慢性感染的假设 肺炎支原体是肺炎发展或恶化的危险因素 哮喘。一组具有临床和病史的受试者 放射学证据显示肺炎支原体和肺炎衣原体感染 大约九年前已被确定。该队列中的所有受试者 通过培养物检测活性支原体或衣原体感染 呼吸道分泌物的聚合酶链反应分析，以及 血清学。将使用呼吸道症状对这些患者进行研究 调查问卷以确定该队列九年来哮喘的患病率 曝光后。根据本研究的问卷调查部分， 将对队列的一个子集进行额外的测试，以进一步 描述临床、生理、炎症和微生物学 这些患者的特征。 这一系列调查旨在确定以下问题的重要性： 非典型细菌感染对疾病发展和临床表型的影响 哮喘。了解支原体和衣原体之间的关联 物种和哮喘对于加深我们对哮喘的了解至关重要 发病机制并为干预措施提供了基础 可以以一级预防为主。将感染识别为风险 慢性哮喘的因素将是我们能力的重大进步 预测哪些患者患哮喘的可能性增加， 将有助于设计和实施有针对性的尝试，以减少 哮喘发病率。 本文所述的调查将作为调查的一部分进行 以患者为中心的综合职业发展计划 研究。有了这个奖项，候选人将接受方法方面的教育 作为公共卫生硕士学位一部分的以患者为中心的研究 哈佛大学公共卫生学院的计划，然后将应用这些技能 在教学环境中学到了实施这项研究的知识 协议。候选人有意利用该奖项来支持自己的职业生涯 确保他作为学术医师科学家取得成功的发展计划 重点是以患者为导向的肺部疾病研究。