Prospective Memory in Normal and Head-Injured Children

正常和头部受伤儿童的前瞻性记忆

• 批准号: 6534725
• 负责人: Stephen Ryan McCauley
• 金额: $ 12.18万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6534725
• 关键词: adolescence (12-20); attention; behavior test; behavior therapy; behavioral /social science research tag; brain imaging /visualization /scanning; child psychology; clinical research; cognition; functional ability; functional magnetic resonance imaging; head /neck injury; human subject; human therapy evaluation; medical rehabilitation related tag; memory; motivation; neural information processing; neuropsychological tests; patient oriented research; performance; postdoctoral investigator; prefrontal lobe /cortex; rehabilitation; short term memory

DESCRIPTION (provided by applicant): This application proposes a four-year period of mentored research training. The candidate's training has been in the area of clinical neuropsychology and he seeks to apply his knowledge of brain-behavior principles and methods of assessment to the designing and completion of studies of individuals with traumatic brain injury (TBI). It is his goal that the knowledge gained from research in this area will lead to future rehabilitation interventions. The candidate's primary short-term goals include the design, implementation, and management of a study of prospective memory (PM) deficits in children and adolescents (age at testing 12-18 years) with TBI under the mentorship of his primary mentor. His primary long-term goal is to become an independent researcher in conducting studies interfacing behavioral data and neuroimaging techniques (specifically fMRI) to improve the understanding of the mechanisms and sequelae of TBI. The candidate's primary mentor has extensive experience in the study of outcome in TBI and the neuroanatomical correlates of behavior, particularly in children and adolescents. One of the secondary mentors is a nationally recognized leader in PM research and another secondary mentor has a strong background in functional neuroimaging. The goal of working with these mentors is to form a collaborative relationship to foster future studies and greater understanding PM in normally-developed children and adolescents, and those with TBI. In addition to research training, the candidate has proposed formal course work and didactics in the areas of advanced statistical analysis, medical physics, neuroscience, rehabilitation, developmental neuroscience, and formal training in the design and implementation of fMRI experiments. He proposes attending a fMRI Training Workshop conducted at UCLA and will work closely with the secondary mentor and the UCLA brain imaging team to implement a fMRI study of PM in normal adolescents. This experience will be applied at Baylor College of Medicine under the supervision of the candidate's Advisory Committee (and consultation with the secondary mentor) where a study of PM will be conducted with children with TBI. The proposed research project has four primary aims. The first aim is to conduct a study investigating a rehabilitation strategy (manipulation of motivation varying degrees of working memory load) to overcome PM deficits in children with TBI. The second aim will examine specific cognitive mechanisms (metamemory, working memory, intention superiority effect, and sustained attention) hypothesized to be involved in PM deficits following TBI. The third aim will investigate the impact of PM deficits on everyday functioning as determined by parent and teacher reports. The fourth aim is to determine which cortical structures (specifically prefrontal cortex) are involved in PM functioning through the use of fMRI.

描述（由申请人提供）：本申请提出为期四年的指导研究培训。 该候选人接受过临床神经心理学领域的培训，他寻求将其大脑行为原理和评估方法的知识应用于设计和完成针对创伤性脑损伤（TBI）个体的研究。 他的目标是从该领域的研究中获得的知识将有助于未来的康复干预。 该候选人的主要短期目标包括在其主要导师的指导下设计、实施和管理一项针对患有 TBI 的儿童和青少年（测试年龄为 12-18 岁）的前瞻性记忆 (PM) 缺陷的研究。 他的主要长期目标是成为一名独立研究人员，开展将行为数据和神经影像技术（特别是功能磁共振成像）结合起来的研究，以提高对 TBI 机制和后遗症的理解。 候选人的主要导师在 TBI 结果和行为的神经解剖学相关性研究（尤其是儿童和青少年）方面拥有丰富的经验。 其中一位二级导师是全国公认的 PM 研究领域的领导者，另一位二级导师在功能性神经影像学方面拥有深厚的背景。 与这些导师合作的目标是建立合作关系，以促进未来的研究并更好地了解正常发育的儿童和青少年以及患有 TBI 的儿童和青少年的 PM。 除了研究培训之外，候选人还提出了高级统计分析、医学物理学、神经科学、康复、发育神经科学领域的正式课程和教学，以及功能磁共振成像实验设计和实施的正式培训。 他提议参加在 UCLA 举办的 fMRI 培训研讨会，并将与二级导师和 UCLA 脑成像团队密切合作，在正常青少年中实施 PM 的 fMRI 研究。 这一经验将在候选人咨询委员会的监督下应用于贝勒医学院（并与第二导师协商），其中将对患有 TBI 的儿童进行 PM 研究。 拟议的研究项目有四个主要目标。 第一个目标是开展一项研究，调查康复策略（操纵不同程度的工作记忆负荷的动机），以克服 TBI 儿童的 PM 缺陷。 第二个目标将检查假设与 TBI 后 PM 缺陷有关的特定认知机制（元记忆、工作记忆、意图优越效应和持续注意力）。 第三个目标是根据家长和老师的报告调查 PM 缺陷对日常功能的影响。 第四个目标是通过使用功能磁共振成像确定哪些皮质结构（特别是前额皮质）参与 PM 功能。