DEVELOPMENT OF HUMAN COCHLEAR FUNCTION

人类耳蜗功能的发育

• 批准号: 6379406
• 负责人: Carolina Abdala
• 金额: $ 9.54万
• 依托单位: HOUSE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379406
• 关键词: age difference; auditory threshold; behavioral /social science research tag; child psychology; clinical research; cochlea; developmental neurobiology; early experience; efferent nerve; human subject; noise; olivocochlear bundle; otoacoustic emission; premature infant human; psychoacoustics; sound frequency

DESCRIPTION: The long-term goal of this project is to investigate the development of human cochlear function. This understanding will provide a framework for more precise identification of cochlear dysfunction, provide support for development and refinement of auditory prostheses and contribute t general theory on human auditory development. The long-term goal will be accomplished by investigating the timecourse and frequency dependent development of (1) cochlear tuning, (2) active cochlear mechanics, and (3) cochlear efferent function using distortion product otoacoustic emission (DPOAE) methodology. DPOAEs are intermodulation products generated by the normal cochlea when it is presented with two tones (f1, f2) simultaneously. They provide a noninvasive, frequency-specific probe of cochlear physiology in humans. This project includes three experiments: 1) In Experiment 1, DPOAE ipsilateral suppression tuning curves will provide an indirect measure of cochlear tuning in neonates ranging from 29 to 36 weeks conceptional age, term infants and normal-hearing adult subjects at five f2 frequencies: 1100, 2500, 5600, 9000 and 12,500 Hz. Suppression tuning curves will be recorded with low-level primary tones to include influence of active cochlear mechanics, and high-leve primary tones to minimize contribution of active cochlear mechanics. Measures of tuning curve width, slope and tip characteristics will be analyzed for age, frequency, and level differences; 2) In Experiment 2, DPOAE growth functions (DPOAE amplitude as a function of primary tone level) will be generated as a measure of active cochlear mechanics or cochlear amplifier activity in human neonates at the same developmental stages and f2 frequencies applied in Experiment 1. DPOAE growth function shape, slope and notch threshold (level of amplitude plateau or decrease) will be analyzed for age and frequency differences; 3) in Experiment 3, contralateral DPOAE suppression will be measured as an index of medial olivocochlear efferent function in human neonates at the same developmental stages and f2 frequencies applied in Experiments 1 and 2. DPOAE growth functions will be recorded with and without broadband noise presented to the opposite ear. The difference between average noise and no noise conditions will be tested to detect contralateral DPOAE suppression. Contralateral DPOAE suppression will be analyzed for age, frequency and level effects. In addition to investigating the independent development of cochlear tuning, active cochlear mechanics and efferent function, these studies will elucidate the relationship among these three aspects of cochlear physiology during human maturation.

描述：该项目的长期目标是调查 人工耳蜗功能的发展。 这种理解将为 框架以更精确地识别人工耳蜗功能障碍，提供 支持开发和完善听觉假体并做出贡献 t人类听觉发展的一般理论。 长期目标将是 通过研究时间和频率依赖性来完成 （1）人工耳蜗调整，（2）主动耳蜗机械和（3）的开发 使用失真产物耳声发射的耳蜗传出功能 （DPOAE）方法论。 DPOAE是由 正常的耳蜗同时呈现两个音调（F1，F2）时。 它们提供了无创，特定于频率的人工耳蜗生理探针 在人类中。 该项目包括三个实验：1）在实验1中，DPOAE 同侧抑制调谐曲线将提供间接的衡量标准 在29至36周的概念时代的新生儿中的耳蜗调整， 在五个F2频率下的术语婴儿和正常听力的成人受试者： 1100、2500、5600、9000和12,500 Hz。抑制调整曲线将是 用低级主音调记录以包括主动的影响 耳蜗力学和高级主音调，以最大程度地减少 主动人工耳蜗。 调谐曲线宽度，坡度和尖端的度量 特征将分析年龄，频率和水平差异； 2）在实验2中，DPOAE生长函数（DPOAE振幅为 主音调水平）将作为主动耳蜗的量度生成 人类新生儿的力学或人工耳蜗放大器活性 实验1中应用的发育阶段和F2频率。 生长功能形状，坡度和缺口阈值（振幅高原水平 或减少）将分析年龄和频率差异； 3）in 实验3，将测量对侧DPOAE抑制作用作为指数 人类新生儿的内侧橄榄石传出功能 实验1和2中应用的发育阶段和F2频率。 DPOAE增长功能将在有或没有宽带噪声的情况下记录 呈现给相反的耳朵。 平均噪声与否之间的区别 将测试噪声条件以检测对侧DPOAE抑制。 将分析对侧DPOAE抑制年龄，频率和 水平效应。 除了调查独立发展 人工耳蜗调整，主动的耳蜗机械和传出功能，这些 研究将阐明这三个方面之间的关系 人的成熟过程中的人工耳蜗生理。