FACE-NAME ASSOCIATION: FMRI STUDIES IN AGING & MILD AD

面孔名称协会：FMRI 衰老研究

• 批准号: 6351776
• 负责人: REISA A. SPERLING
• 金额: $ 14.32万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6351776
• 关键词: Alzheimer's disease; age difference; aging; association learning; behavioral /social science research tag; bioimaging /biomedical imaging; biomarker; brain mapping; clinical research; functional magnetic resonance imaging; human subject; memory; memory disorders; psychological aspect of aging; psychological identification

DESCRIPTION (Adapted from the application): This is an application for a K23-Mentored Patient-Oriented Career Development Award entitled "Face-Name Association: fMRI Studies in Aging & Mild AD". The primary goal of the proposed research is to utilize fMRI to investigate the functional networks subserving "relational" explicit memory tasks, such as face-name association, and to examine the alterations in this network that occur in normal aging and mild AD. The ability to learn and remember associations between components of newly acquired information, such as names and faces, is an essential memory requirement of everyday life. Moreover, difficulty recalling proper names is the most common memory complaint of older individuals, raising fears of an underlying neurodegenerative disease, such as Alzheimer s disease (AD). Functional MRI (fMRI) is a powerful new technique for investigating the neural substrates of cognition, and provides an excellent opportunity to study complex memory processes, such as face-name association. It is hypothesized that face-name association will require the integration of multiple brain regions, including the fusiform gyrus, dorsolateral prefrontal cortex and the hippocampal formation, that will be differentially affected by the processes of normal aging and mild AD. An integrated series of cognitive and imaging studies is planned to address the following questions: 1) What is the functional anatomy of memory for face-name associations in young individuals? 2) What functional alterations occur in the brain during these tasks with normal aging? 3) How are the functional changes that occur in mild AD different from those seen in normal aging? 4) Is it feasible to develop fMRI during face-name association tasks as a surrogate marker of response to pharmacologic therapy in AD patients? This functional dissection of the explicit memory network using a clinically relevant task will provide new and important insights about memory alterations that occur with age and in early AD. In order to achieve these goals, the candidate seeks training in 1) fMRI physics and analytic techniques, 2) cognitive neuroscience methodology relevant to explicit memory, and 3) clinical research design and analysis. The proposed research plan, didactic courses, and tutorial instruction from mentors and advisors will serve to foster the candidate's development into an independent clinical researcher in the field of functional neuroimaging and neurodegenerative disease.

描述（根据应用程序改编）：这是 K23由以患者为导向的职业发展奖的标题为“ face-name 协会：衰老和轻度AD的fMRI研究”。 拟议的研究是利用fMRI来研究功能网络 扩展“关系”明确的内存任务，例如face-name关联， 并检查正常衰老和 轻度广告。 学习和记住新的组成部分之间的关​​联的能力 获取的信息（例如名称和面孔）是必不可少的记忆 日常生活的要求。 而且，难以回忆专有名称是 老年人最常见的记忆投诉，引起了人们对 潜在的神经退行性疾病，例如阿尔茨海默氏病（AD）。 功能性MRI（fMRI）是一种用于研究神经的强大新技术 认知的底物，并提供了学习的绝佳机会 复杂的内存过程，例如面名关联。 它是假设的 该面名的关联将需要多个大脑的整合 区域，包括梭形回，背侧前额叶皮层和 海马形成，将受到这些过程的差异影响 正常衰老和轻度AD。 一系列集成的认知和成像研究，以解决 以下问题：1）记忆的功能解剖学是什么 年轻人的面名联想？ 2）什么功能更改 在正常衰老的这些任务中，发生在大脑中吗？ 3）如何 轻度AD中发生的功能变化与正常情况下的功能变化不同 老化？ 4）在面名协会任务中开发fMRI是否可行 作为AD患者对药理疗法反应的替代标记？ 使用临床上的显式记忆网络的功能解剖 相关任务将提供有关内存更改的新重要见解 这是随着年龄的增长而发生的。 为了实现这些目标，候选人在1）fMRI中寻求培训 物理和分析技术，2）认知神经科学方法论 与显式记忆有关，3）临床研究设计和分析。 拟议的研究计划，教学课程和教程指导 导师和顾问将有助于促进候选人的发展 功能性神经影像领域的独立临床研究人员和 神经退行性疾病。