CORE--MUSCLE PHYSIOLOGY

核心--肌肉生理学

• 批准号: 6299878
• 负责人: JON F WATCHKO
• 金额: $ 17.11万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6299878
• 关键词: biomedical facility; dystrophin; gene therapy; hamsters; laboratory mouse; muscle contraction; muscle function; muscular dystrophy; transfection /expression vector

The Muscle Physiology Core is a well equipped in vitro physiology laboratory staffed with experienced personnel skilled in executing personnel skilled in executing the proposed contractile studies. This Core will be supervised by Jon Watchko, M.D., and be available to all principal investigators assisting them in achieving their research goals evaluating the effects of gene therapy on skeletal muscle function. In addition to meeting the overlapping needs of individual projects and thereby being the most efficient use of space, equipment and personnel talent, this Core will enhance collaboration between investigators. The Specific Aims of the Muscle Physiology ore are to i) obtain natural history data on muscle function of the tibialis anterior in normal and dystrophic (dystrophin-deficient mdx) mice, and normal and dystrophic cardiomyopathic) hamsters, and ii) determine the positive or negative effects of viral vector gene delivery on contractile function of the tibialis anterior muscle of dystrophin deficient mice and delta- sarcoglycan hamsters.

肌肉生理学核心是一个装备精良的体外生理学 实验室配备了经验丰富、执行能力强的人员 熟练执行所提议的收缩研究的人员。这 Core 将由医学博士 Jon Watchko 监督，并向所有人开放 主要研究人员协助他们实现研究目标 评估基因治疗对骨骼肌功能的影响。在 除了满足各个项目的重叠需求之外 从而最有效地利用空间、设备和人员 人才，这个核心将加强调查人员之间的合作。这 肌肉生理学矿石的具体目标是 i) 获得天然 正常人和胫骨前肌功能的历史数据 营养不良（肌营养不良蛋白缺乏 mdx）小鼠，以及正常和营养不良 心肌病）仓鼠，以及 ii）确定阳性或阴性 病毒载体基因传递对收缩功能的影响 肌营养不良蛋白缺陷小鼠的胫骨前肌和δ- 肌聚糖仓鼠。