AN INTERFEROMETRIC DETECTOR FOR MICROFLUIDIC DEVICES

用于微流体装置的干涉检测器

• 批准号: 6363202
• 负责人: MICHAEL L CHABINYC
• 金额: $ 1.74万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6363202
• 关键词: analytical method; bioengineering /biomedical engineering; biomaterial development /preparation; biosensor device; fluid; interferometry; microarray technology; molecular assembly /self assembly; monitoring device; optics; spectrometry

New technology and cost reductions in analytical methods are required for genomic and proteomic research projects. Microfluidic devices show promise as a solution for the analytical needs of these projects. The specific aim of this research is to develop an interferometric refractive index detection scheme for biological analytes in microfluidic devices. Interferometric refractive index detectors are highly sensitive and nonspecific. They will eliminate the need for development of fluorescent tags for proteins and carbohydrates. The fluidic and optical elements will be fabricated from polymers using soft lithography. The use of polymers will increase the flexibility of microanalytical systems and also lower their cost.

基因组和蛋白质组学研究项目需要新技术和分析方法的成本降低。微流体设备显示出有望作为解决这些项目的分析需求的解决方案。 这项研究的具体目的是为微流体设备中的生物分析物开发一种干涉折射率检测方案。干涉折射率检测器高度敏感且非特异性。 他们将消除开发蛋白质和碳水化合物的荧光标签的需求。 流体和光学元件将使用软光刻从聚合物制成。 聚合物的使用将提高微分析系统的灵活性，并降低其成本。