Neural Mechanisms of Hemifacial Spasm

面肌痉挛的神经机制

• 批准号: 6551869
• 负责人: IRIS S KASSEM
• 金额: $ 2.3万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-17 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6551869
• 关键词: antidromic impulse; artery; clinical research; electrostimulus; eye movement disorders; eyelids; facial muscles; facial nerve; human subject; laboratory rat; motor neurons; neuroregulation; pathologic process; reflex; sign /symptom; spasm; trigeminal nerve

DESCRIPTION (provided by applicant): Hemifacial spasm generally begins as involuntary muscle spasms in the eyelids and then progresses to the entire distribution of the facial nerve. This disease is thought to be due to a compression of the facial nerve at its root entry zone by one of several arteries in the region. The underlying neural mechanisms of the hemifacial spasm are still controversial. Arterial compression of the nerve can modify the facial nerve, facial motoneurons, and the trigeminal nucleus. This proposal investigates the role of each of these modifications in producing the symptoms of hemifacial spasm. Hemifacial spasm patients will used to identify changes in the trigeminal system. An animal model isolating the different mechanisms will be created to characterize the causes of symptom development resulting from motoneuron and trigeminal modifications.

描述（由申请人提供）：半径痉挛通常以眼睑的非自愿性肌肉痉挛开始，然后发展为面神经的整个分布。人们认为该疾病是由于该地区的几个动脉之一在其根部进入区域的面神经压缩所致。半径痉挛的潜在神经机制仍然存在争议。神经的动脉压缩可以改变面神经，面部运动神经元和三叉神经核。该提案研究了每种修饰在产生下半径痉挛症状中的作用。半径痉挛患者将使用三叉神经系统的变化。将创建分离不同机制的动物模型，以表征由运动神经元和三叉神经修饰引起的症状发展的原因。