Core--Clinical evaluation

核心--临床评价

• 批准号: 6339877
• 负责人: HAROLD A. SACKEIM
• 金额: $ 26.01万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-03 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6339877
• 关键词: biomedical facility; clinical research; human subject; medical outreach /case finding; patient /disease registry; suicide

The Clinical Evaluation Core's goals are to: (1) recruit, characterize, and follow all human subjects participating in projects #2-7 of the CCNMD (2) develop and maintain state-of-the-art methods for clinical characterization of human framework for testing the stress-diathesis model of suicidal behavior. The CEC identified and recruits patients with MDE, BPD, and Schizophrenia across the life cycle (and post-mortem). Normal volunteers are recruited to provide normative values on the clinical and neurobiological measures used and to establish psychometric properties of measures in a non-pathological population. The CEC utilizes a core of clinical/neuropsychological instruments covering major risk factor domains for suicidal behavior, and ensures uniformity of assessment domains and measures across the projects of the CCNMD. These assessments include Axis I and II diagnostic interviews, measures of state and trait-related risk factors, neuropsychological assessment, measures of suicidal behavior, demographic history, life events, social functioning, family psychiatric history. Assessments are performed at intake, at time of biological procedures, at discharge, at 3 month, 1 and 2 year follow-up. The CEC investigates, develops and tests new assessment procedures to address current and future needs in the field of suicide research, and regularly reviews the reliability and validity of instruments. The CEC ensures the quality of clinical assessments through inter-rater reliability rounds using live or taped interviews. On all measures, our faculty provides consultation to investigators in research methodology and result interpretation. The CEC faculty provides consultation to investigators in research methodology and result interpretation. The CEC has successfully recruited and followed adequate members of life subjects in the proposed diagnostic and age categories. The training and reliability of all CCNMD raters is coordinated by the CEC. The CEC works with SCC staff in developing forms, data management procedures and in generating reliability statistics The CEC coordinates with the BIC regarding recruitment, interviewing, control matching and subject flow. The CEC obtains the blood and cerebrospinal fluid from subjects to be analyzed by the CLC. The CEC interfaces with the Administrative Core regarding recruitment of new staff and maintenance of a central database of all CEC manuscripts. The CEC coordinates all diagnostic consensus conferences.

临床评估核心的目标是：（1）招募，特征和 关注所有参加CCNMD项目＃2-7项目的人类受试者 （2）开发和维护临床的最新方法 人类测试应力分析框架的表征 自杀行为的模型。 CEC确定并招募患者 在整个生命周期（和验尸）中，MDE，BPD和精神分裂症。 招募正常志愿者以在 临床和神经生物学措施使用并建立心理计量学 非病理人群中度量的特性。 CEC使用 涉及主要风险的临床/神经心理学仪器的核心 自杀行为的因素域，并确保 CCNMD项目的评估领域和措施。 这些评估包括轴I和II诊断访谈，措施 国家和特征相关的危险因素，神经心理学评估， 自杀行为，人口历史，生活事件，社会的衡量标准 功能，家庭精神病史。评估是在 在生物学程序时，在出院时，3个月，1和2的摄入量 一年随访。 CEC调查，开发和测试新评估 解决自杀领域当前和未来需求的程序 研究，并定期审查工具的可靠性和有效性。 CEC通过评估者确保临床评估的质量 可靠性回合使用现场或录音采访。在所有措施上，我们 教师为研究方法提供咨询 和结果解释。 CEC教师向 研究方法和结果解释的研究者。 CEC 已经成功招募并遵循了足够的生活学科成员 在拟议的诊断和年龄类别中。培训和可靠性 所有CCNMD评估者均由CEC协调。 CEC与 SCC员工开发形式，数据管理程序和IN 生成可靠性统计数据CEC与BIC坐标 关于招聘，访谈，控制匹配和主题流。 CEC从受试者获得血液和脑脊液 由CLC分析。 CEC与管理核心的接口 关于招募新员工和中央数据库的维护 在所有CEC手稿中。 CEC协调所有诊断共识 会议。