Core F -Clinical Science Core

核心 F - 临床科学核心

基本信息

批准号：
10458375
负责人：
Kara W Chew
金额：
$ 21.01万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-08 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10458375
关键词：
AIDS clinical trial group Affect Aging Area Behavioral Behavioral Research Biomedical Research California Clinic Clinical Clinical Data Clinical Informatics Clinical Protocols Clinical Sciences Cohort Studies Collaborations Collection Communities Conceptions Consent Forms Consultations Data Development Electronic Health Record Epidemic Ethics Committees Funding Goals Grant HIV HIV Seropositivity HIV prevention trials network Human Human Subject Research Individual Institutional Review Boards International Intervention Investigational New Drug Application Laboratories Lead Link Los Angeles Mission Monitor Participant Patient Recruitments Pharmacy facility Policies Population Prevention Process Protocols documentation Registries Research Research Design Research Personnel Research Training Resources Sampling Science Services Specimen Standardization Statistical Methods Targeted Research Time Training Training Support Training and Education Translational Research Translations Underrepresented Populations Universities University resources Veterans Vulnerable Populations Work base clinical research site community engagement design early phase trial efficacious intervention experience first-in-human high reward high risk human subject implementation framework implementation science institutional biosafety committee interest novel patient oriented patient oriented research pre-clinical prevent prospective protocol development research study sociodemographics symposium volunteer

项目摘要

CORE F: PROJECT SUMMARY/ABSTRACT. The Clinical Science Core provides support for clinical, basic/translational, and behavioral investigators in the conduct of HIV-related research involving human subjects at the University of California, Los Angeles (UCLA), Charles Drew University (CDU), and affiliated centers. The goal of Core F is to support the translation of preliminary and pre-clinical data and ideas into clinical/human studies that advance HIV science and lead to interventions with potential quantifiable impact on the HIV epidemic. The Core will do this by reducing identified barriers to the development and implementation of patient- oriented research. The Core has two Specific Aims: 1. To provide support and training to investigators in the regulatory approval and implementation aspects of biomedical, behavioral, and basic translational patient- oriented research in HIV, and 2. To facilitate patient-oriented research in HIV by increasing access to research participants and generating new collaborations and concepts. The Core offers a streamlined process and consultative services to reduce the time between project conception and funding (supporting clinical protocol development and feasibility assessment for successful grant submissions); reduce the time between funding and the initiation and completion of the research; train and support new investigators and established investigators new to patient-oriented research in regulatory, design, and implementation aspects of human subjects research, to move novel and efficacious interventions from the lab to the clinic (domestically and globally); support mechanistic work that can lead to clinical interventions by increasing access to human samples; promote collaboration through linkage to HIV research networks and data; and engage underrepresented populations in HIV research through the Research Study Volunteer Project (RSVP), a Core-sponsored volunteer registry for individuals with and without HIV interested in participating in HIV-related research, to generate the most informative prevention and treatment studies in key populations. All services of the Core will support both domestic and internationally based research initiatives.

核心F：项目摘要/摘要。临床科学核心为临床提供支持，基本/翻译和行为研究者在涉及人类受试者的HIV相关研究中在加利福尼亚大学，洛杉矶分校（加州大学洛杉矶分校），查尔斯·德鲁大学（CDU）和附属中心。这核心F的目标是支持将初步和临床前数据和思想转化为临床/人提高艾滋病毒科学并导致对艾滋病毒有潜在可量化影响的干预措施的研究流行性。核心将通过减少确定的患者发展和实施障碍来做到这一点。定向研究。核心有两个具体的目标：1。向调查人员提供支持和培训生物医学，行为和基本转化患者的监管批准和实施方面艾滋病毒的定向研究和2。通过增加研究的机会来促进艾滋病毒的艾滋病毒研究参与者并产生新的合作和概念。核心提供了简化的过程，咨询服务以减少项目构想和资金之间的时间（支持临床协议成功赠款提交的发展和可行性评估）；减少资金和研究的启动和完成；培训并支持新的调查人员，并建立了调查员人类受试者研究的监管，设计和实施方面研究的新知识研究，将新颖有效的干预措施从实验室转移到诊所（在国内和全球）；支持通过增加获得人类样本的机会，可以导致临床干预的机理工作；推动通过与艾滋病毒研究网络和数据联系的协作；并参与代表性不足的人群艾滋病毒研究通过研究研究志愿者项目（RSVP），这是由核心赞助的志愿者注册表患有和没有艾滋病毒的人有兴趣参与与HIV相关的研究，以产生最多的人关键人群的信息预防和治疗研究。核心的所有服务都将支持两者国内和国际研究计划。