RISK FACTORS FOR UTI IN POST MENOPAUSAL WOMEN

绝经后女性尿路感染的危险因素

• 批准号: 6177067
• 负责人: STEPHAN D FIHN
• 金额: $ 21.57万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6177067
• 关键词: clinical research; diabetes mellitus; disease /disorder proneness /risk; estrogens; female; hormone therapy; human morbidity; human subject; interview; postmenopause; sex behavior; urinalysis; urinary incontinence; urinary tract infection; urination; women's health

DESCRIPTION: UTI is one of the commonest infections i women, occurring in nearly 20% during their lifetime and costing nearly $1 billion annually. Research on the epidemiology and aetiology of UTI has concentrated on two groups of women: the young and healthy and the elderly and debilitated. In younger women, general debility, voiding problems, diabetes, and possibly, estrogen deficiency are risk factors. Little is known about risk factors for UTI in women soon after menopause, even though there are 56 million women aged 50 to 75. The main goal of this project is to prospectively determine the incidence of acute UTI and to assess risk factors for this problem in postmenopausal women, aged 50 to 75, living in the community. The primary aims will be to learn the relative effects of diabetes, postmenopausal estrogens, urine incontinence or increased post-void residual urine, and sexual activity on the risk of UTI. There are also plans to determine whether changes in the vaginal bacterial flora predispose to UTI in this age group and how risk factors, such as diabetes and estrogen therapy affect the vaginal flora. A prospective cohort study of community-dwelling, postmenopausal women is proposed. Participants will be 900 women randomly selected from the Group Health Cooperative of Puget Sound (GHC) enrollment database, along with 110 age-matched women, randomly selected from the GHC Diabetes Registry. Information about sexual activity,estrogen use, history of UTI, urinary continence and other exposures of interest will be obtained by interview. Urine and vaginal introital cultures along with measurement of the fasting serum glucose and the post-void residual urine volume will be performed at a clinic visit. Follow-up interviews and examinations will be performed annually for two years. Diabetic patients will be followed with glycosylated hemoglobin at least annually. Patients will monitor their urine monthly at home with leukocyte esterase/nitrite dipsticks and make a clinic visit if they test positive.

描述：尿路感染是女性最常见的感染之一，发生在 在其一生中消耗近 20%，每年花费近 10 亿美元。 UTI的流行病学和病因学研究集中在两个方面 妇女群体：年轻健康的妇女和年老体弱的妇女。 在 年轻女性、全身虚弱、排尿问题、糖尿病，以及可能， 雌激素缺乏是危险因素。 对风险因素知之甚少 尽管有 5600 万人患有绝经后不久的女性尿路感染 50至75岁的女性。该项目的主要目标是前瞻性地 确定急性尿路感染的发生率并评估其危险因素 居住在社区的 50 至 75 岁绝经后妇女的问题。 主要目标是了解糖尿病的相对影响， 绝经后雌激素、尿失禁或排尿后残留增加 尿液和性活动对尿路感染风险的影响。 也有计划 确定阴道菌群的变化是否容易导致尿路感染 在这个年龄段，糖尿病和雌激素等危险因素如何 治疗会影响阴道菌群。 一项针对社区绝经后妇女的前瞻性队列研究 建议的。 参与者将从小组中随机选出 900 名女性 普吉特湾健康合作社 (GHC) 注册数据库，以及 110 从 GHC 糖尿病登记处随机选择的年龄匹配的女性。 有关性活动、雌激素使用、尿路感染病史、泌尿系统的信息 失禁和其他感兴趣的暴露将通过面谈获得。 尿液和阴道口培养以及禁食测量 血糖和排尿后残余尿量将在 门诊就诊。 将进行后续面试和考试 每年一次，持续两年。 糖尿病患者将接受随访 至少每年检测一次糖化血红蛋白。 患者将监测他们的 每月在家用白细胞酯酶/亚硝酸盐试纸检测尿液并制作 如果检测结果呈阳性，请前往诊所就诊。