National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Core Project

全国青少年至成人健康纵向研究（添加健康）：第六波核心项目

基本信息

批准号：
10166116
负责人：
ROBERT A HUMMER
金额：
$ 599.48万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10166116
关键词：
Address Adolescent Adult Age Age-Years Aging Alcoholic Liver Diseases Alcohols Alzheimer&apos s disease related dementia American Ancillary Study Archives Attention Behavior Behavioral Biological Biological Assay Biological Markers Birth Certificates Blood Blood Pressure COVID-19 COVID-19 pandemic Cardiometabolic Disease Cardiovascular Diseases Chronic Cognitive Collection Communities Companions Consent Country Data Data Collection Data Files Death Certificates Dimensions Discrimination Disease Drug abuse Drug usage Economics Elderly Epigenetic Process Ethnic Origin Exhibits Future Gender Gene Expression Genetic Markers Geography Goals Health Health Surveys Heavy Drinking Home Interview Intoxication Life Cycle Stages Link Longitudinal Studies Malignant Neoplasms Measures Mental Health Neighborhoods Online Systems Pain Parents Participant Persons Pharmaceutical Preparations Physical Function Positioning Attribute Reporting Research Personnel Rural Sampling Schools Science Secure Social Change Socioeconomic Status Specimen Stress Substance abuse problem Suicide Venous Visit Work adult obesity base career life balance caregiving cohort cost data dissemination disadvantaged population ethnic minority population follow-up health care economics health disparity innovation low socioeconomic status member microbiome middle age mortality pandemic disease psychosocial racial and ethnic racial disparity residence response sexual minority social socioeconomics trend urban residence

项目摘要

Project Summary This project, developed in response to RFA-AG-21-008, describes core plans for data collection and dissemination of the sixth wave (Wave VI) of the National Longitudinal Study of Adolescent to Adult Health (Add Health), when cohort members will be 39-48 years of age (mean 44). Add Health is a longitudinal study of a nationally representative sample of over 20,000 adolescents who were in grades 7-12 during the 1994-95 school year and have been followed for five waves to date. Over 25 years, Add Health has collected rich demographic, social, familial, socioeconomic, behavioral, psychosocial, cognitive, and health survey data from participants and their parents; a vast array of contextual data from participants' schools, neighborhoods, and geographies of residence; administrative data linked to participants, including birth and death certificates; and in-home physical and biological data from participants, including anthropometric measures, genetic markers, blood-based assays, and medications. Ancillary studies have added more information, including epigenetic, gene expression, and microbiome data. Thus, Add Health is exceptionally unique because it has a rich, multi- level, longitudinal array of data for a large nationally representative cohort of Americans who are entering midlife. Importantly, the overall health profile of the cohort as they make the transition to midlife is problematic across many dimensions. Moreover, health disparities by race, ethnicity, gender, socioeconomic status, sexual minority status, and rural-urban residence in this cohort are wide and, in some cases, widening. As such, rich longitudinal, multi-level, and nationally representative data are urgently needed to best understand the life course determinants of health trajectories and health disparities of US adults as they enter midlife. Wave VI of Add Health will fill this critical need. The overall goal of Wave VI of Add Health is to collect and disseminate the comprehensive data needed to best understand the social, economic, psychosocial, contextual, and biological determinants of health trajectories and disparities among this nationally representative cohort of Americans as they age into midlife. The project is focused around five aims: 1) Re-interviewing cohort members using predominantly web-based and in-person modes, with explicit attention to securing high response rates from racial/ethnic minority and low socioeconomic status participants; 2) Enriching study content in key domains that will elucidate mid- and later-life health trajectories and disparities; 3) Re-visiting cohort members who consent for an in-home health exam that includes venous blood collection and other important components of health; 4) Assaying biological specimens for important pre-disease and disease biomarkers; and 5) Cleaning, documenting, disseminating, archiving, promoting, and supporting Wave VI data for the scientific community. This project has extraordinary potential to contribute to the science of aging, health, and health disparities for decades to come, as the Add Health cohort ages into the middle adult years and beyond. Successful carryout of this project will supply essential data for thousands of researchers working on these critical issues.

项目概要该项目是根据 RFA-AG-21-008 开发的，描述了数据收集和处理的核心计划全国青少年至成人健康纵向研究第六波（第六波）的传播（添加健康），队列成员年龄为 39-48 岁（平均 44 岁）。添加健康是一项纵向研究 1994-95 年期间超过 20,000 名 7-12 年级青少年的全国代表性样本学年，迄今为止已追踪五波。 25 年来，Add Health 收集了丰富的人口统计、社会、家庭、社会经济、行为、心理社会、认知和健康调查数据参与者及其父母；来自参与者的学校、社区和社区的大量背景数据居住地区；与参与者相关的管理数据，包括出生和死亡证明；和参与者的家庭身体和生物数据，包括人体测量、遗传标记、基于血液的检测和药物治疗。辅助研究添加了更多信息，包括表观遗传、基因表达和微生物组数据。因此，Add Health 非常独特，因为它具有丰富的、多方面的水平，大量具有全国代表性的美国人群体的纵向数据阵列中年。重要的是，该群体在过渡到中年时的整体健康状况存在问题跨越多个维度。此外，因种族、族裔、性别、社会经济地位、性取向而存在的健康差异该群体中的少数民族身份和城乡居民分布广泛，在某些情况下还在扩大。如此一来，富有迫切需要纵向、多层次、具有全国代表性的数据来更好地了解生活美国成年人进入中年时的健康轨迹和健康差异的过程决定因素。第六波添加健康将满足这一关键需求。 Add Health Wave VI 的总体目标是收集和传播最好地了解社会、经济、心理、背景和生物所需的综合数据健康轨迹的决定因素以及这群具有全国代表性的美国人之间的差异他们步入中年。该项目重点围绕五个目标：1）使用主要是基于网络和面对面的模式，并明确关注确保高响应率少数种族/族裔和社会经济地位较低的参与者； 2）丰富重点领域的学习内容将阐明中年和晚年的健康轨迹和差异； 3) 重新拜访同意的队列成员进行家庭健康检查，包括静脉血采集和其他重要的健康组成部分； 4）分析生物样本中重要的病前和疾病生物标志物； 5) 清洁，为科学界记录、传播、存档、推广和支持 Wave VI 数据。该项目具有非凡的潜力，可为老龄化、健康和健康差异科学做出贡献未来几十年，随着“添加健康”人群步入中年及以后。成功执行该项目将为数千名研究这些关键问题的研究人员提供必要的数据。