MODERATE ALCOHOL, FUNCTION, AND HEALTH OF OLDER WOMEN

适量饮酒、功能和老年女性的健康

• 批准号: 6168338
• 负责人: HEIDI NELSON
• 金额: $ 10.3万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6168338
• 关键词: alcoholic beverage consumption; behavioral /social science research tag; clinical research; disease /disorder proneness /risk; female; functional ability; health surveys; human morbidity; human mortality; human old age (65+); human subject; longitudinal human study; neuromuscular function; questionnaires; smoking; substance abuse epidemiology; women's health

This study will examine the health risks and benefits of moderate alcohol use in women by analyzing previously collected data from the Study of Osteoporotic Fractures (SOF). SOF is an ongoing, multi-center, prospective cohort study of risk factors for osteoporosis and fractures including 9,704 older women enrolled in 1986-1987. Specific aims include: 1) a longitudinal analysis of associations between moderate alcohol use and tests of neuromuscular and physical function previously found to be a significant and beneficial relationship on cross-sectional analysis by the principal investigator; 2) assessment of the influence of moderate alcohol use on selected incident morbidities, institutionalization, and mortality; 3) identification of subgroups of women for whom moderate alcohol use is particularly harmful for application in the development of alcohol use guidelines; and 4) description of the patterns, context, and attitudes of alcohol use among older women to determine if the beneficial effects of alcohol represent alcohol consumption itself, or if it serves as a marker for higher physical and social function. SOF data were collected using interviewer- administered questionnaires, physical examinations, and selected radiographic and laboratory tests for all subjects at one of four clinic sites on four separate occasions. Alcohol use including age of first use, age of discontinuation, and current and past frequency of use was ascertained by questionnaire at visit 1, and current status was reascertained at visit 4. Additional data on alcohol use patterns will be collected by a supplemental questionnaire from a sub-sample of 1,900 SOF participants at the Portland, Oregon site during the course of the study. Many variables such as functional status, physical performance measures, and depression scales have been collected in a serial manner, allowing assessment of changes in health status. Results would be applicable to large populations of older women providing information for appropriate alcohol use decisions. Relationships between variables will be examined using multiple linear and logistic regression models predominantly.

这项研究将检查适度酒精的健康风险和益处 通过分析先前收集的数据从研究中使用 骨质疏松骨折（SOF）。 SOF是一项持续的，多中心的，前瞻性的危险因素研究 用于骨质疏松和骨折，包括9,704名年长妇女 1986-1987。 具体目的包括：1）对 中等酒精使用与神经肌肉测试之间的关联和 以前发现的身体功能是重要而有益的 首席研究员在横断面分析上的关系； 2） 评估中等饮酒对选定事件的影响 病态，制度化和死亡率； 3）识别 适度使用饮酒特别有害的妇女亚组 用于制定酒精使用指南；和4） 对酒精使用的模式，背景和态度的描述 老年妇女确定酒精的有益影响是否代表 饮酒本身，或者如果它可以作为更高的标记 身体和社会功能。 使用访调员收集SOF数据 - 管理问卷，身体检查和选定 四个诊所之一的所有受试者的放射学和实验室测试 站点在四个不同的场合。 酒精使用，包括初期年龄， 中断的年龄以及当前和过去的使用频率是 由问卷确定在访问1时，当前状态为 在访问4中重新确定。有关酒精使用模式的其他数据将是 由1,900个子样本的补充问卷收集 在研究过程中，俄勒冈州波特兰的参与者。 许多变量，例如功能状态，身体绩效指标， 和抑郁量表已经以序列方式收集，允许 评估健康状况的变化。 结果将适用于 大量的老年妇女提供信息 酒精使用决定。 将检查变量之间的关系 主要使用多个线性和逻辑回归模型。