BIOCHEMISTRY AND IMMUNOLOGY OF ALCOHOLIC LIVER DISEASE

酒精性肝病的生物化学和免疫学

• 批准号: 6341470
• 负责人: THOMAS R JERRELLS
• 金额: $ 19.79万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6341470
• 关键词: BIOCHEMISTRY; IMMUNOLOGY; ALCOHOLIC; LIVER; DISEASE

DESCRIPTION: Alcoholic liver disease is a serious world-wide problem. Although a large amount of research has been done to determine the mechanisms that are responsible for liver damage associated with alcohol abuse it is still not clear what the mechanisms are that result in hepatocyte damage. There is a need for well-trained basic scientists to do research on the cellular and molecular biological aspects of alcoholic liver disease. It is a very recent finding that alcohol abuse is associated with a more severe hepatitis caused by hepatitis C virus, which has further supported the suggestion that there is an association between the suppression of immune responses and an increased susceptibility to infectious agents such as the hepatitis viruses. Very little information is available regarding the mechanisms that lead to more severe infections with these viruses and there is a clear need for individuals trained in this aspect of alcohol's effects. There is a need for clinically trained researchers with an understanding of research. The creation of numerous MD/PhD programs has been proposed to fill the need for research-trained clinicians. It is one aspect of the proposed training grant to train MD/PhD students to assume positions where clinical research on the mechanisms of alcoholic liver disease can be performed. It is proposed that the training faculty located at the Omaha VA Medical Center in Omaha, in collaboration with investigators at the University of Nebraska Medical Center and Creighton University, train pre-doctoral (including MD/PhD students) and post-doctoral students in research in the fundamental mechanisms of alcoholic Ever disease. 'Me training faculty have academic appointments at the University of Nebraska Medical Center and are actively funded to do research and have extensive experience in training pre- and post-doctoral students. Given the expertise of the training faculty, the extensive resources available to the trainees and the multidisciplinary approach to research on alcoholic liver disease at the Omaha VA research unit it is likely that each trainee will be well qualified to continue a research career in alcohol research. The ultimate goal of this training program is to prepare both basic scientists and clinically trained scientists for an active and productive research career on the effects of alcohol on the liver.

描述： 酒精性肝病是一个严重的世界性问题。虽然大 已经进行了大量的研究来确定其机制 它仍然不是与酗酒相关的肝损伤的原因 明确导致肝细胞损伤的机制是什么。有一个 需要训练有素的基础科学家来进行细胞和 酒精性肝病的分子生物学方面。这是最近的 发现酗酒与更严重的肝炎有关 丙型肝炎病毒，这进一步支持了以下建议： 免疫反应抑制与免疫反应增加之间的关联 对肝炎病毒等传染源的易感性。很少 现有关于导致更严重的机制的信息 感染这些病毒并且个人有明确的需求 受过酒精影响这方面的培训。 需要经过临床训练的研究人员了解 研究。已提议设立许多医学博士/博士课程来填补 需要经过研究培训的临床医生。这是提议的一方面 培训补助金，用于培训医学博士/博士生担任临床职位 可以进行酒精性肝病发病机制的研究。 建议将培训师设在奥马哈 VA 医疗中心 奥马哈中心与奥马哈大学的研究人员合作 内布拉斯加州医学中心和克赖顿大学培养博士生 （包括MD/PhD学生）和从事研究的博士后学生 酒精性埃弗病的基本机制。 '我的培训教师有 内布拉斯加大学医学中心的学术任命 积极资助开展研究，并在预培训方面拥有丰富的经验 和博士后学生。 鉴于培训教师的专业知识、丰富的可用资源 给学员和酒精研究的多学科方法 在奥马哈退伍军人管理局研究单位的肝病中，每个学员很可能 将有资格继续从事酒精研究的研究生涯。这 该培训计划的最终目标是培养基础科学家和 受过临床训练的科学家从事积极而富有成效的研究生涯 酒精对肝脏的影响。