TRAINING PROGRAM IN CANCER BIOLOGY

癌症生物学培训计划

• 批准号: 2894412
• 负责人: HENRY R BOSE
• 金额: $ 8.95万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2894412
• 关键词: TRAINING; PROGRAM; CANCER; BIOLOGY

DESCRIPTION: Program Characteristics: This application is a revision of a renewal application requesting continuing support for a cancer biology training program at the University of Texas at Austin to provide predoctoral training in basic multidisciplinary research in tumor biology. The major goal is to train excellent scientists who will subsequently pursue successful independent research in tumor biology. Training emphasis derives from the strengths of the training faculty and will be in the areas of chemical and viral carcinogenesis, immunology, and cellular and molecular biology. Trainees will be drawn from students who have matriculated in the Department of Microbiology, the Molecular Biology Program, and the Division of Biological Sciences Graduate Programs of the Graduate School of the University of Texas at Austin. All trainees will be required to take a core series of courses in cell and molecular biology and to complete graduate level courses in immunobiology, fundamentals of tumor biology, virology, and mechanisms of carcinogenesis. Trainees will also participate in short, highly focused courses in research techniques and in various aspects of carcinogenesis and tumor biology. Past courses have included transcriptional control, RNA processing, oncogenes and signalling. Opportunities also exist for trainees to attend the NCI-sponsored tumor biology course at Keystone, Colorado.

描述： 计划特点：本申请是续订申请的修订版，要求继续支持德克萨斯大学奥斯汀分校的癌症生物学培训计划，以提供肿瘤生物学基础多学科研究的博士前培训。 主要目标是培养优秀的科学家，他们随后将在肿瘤生物学方面取得成功的独立研究。培训重点源自培训师资力量，将集中在化学和病毒致癌、免疫学以及细胞和分子生物学领域。 学员将从德克萨斯大学奥斯汀分校研究生院微生物学系、分子生物学项目和生物科学研究生项目部的学生中选拔。 所有学员都需要学习细胞和分子生物学的核心系列课程，并完成免疫生物学、肿瘤生物学基础、病毒学和致癌机制的研究生课程。学员还将参加有关研究技术以及癌发生和肿瘤生物学各个方面的短期、高度集中的课程。 过去的课程包括转录控制、RNA 加工、癌基因和信号传导。学员还有机会参加 NCI 在科罗拉多州基斯通举办的肿瘤生物学课程。

项目成果

Rel-associated pp40: an inhibitor of the rel family of transcription factors.

Rel 相关 pp40：转录因子 rel 家族的抑制剂。

• 发表时间: 1991-09-13
• 作者: Davis, N;Ghosh, S;Simmons, D L;Tempst, P;Liou, H C;Baltimore, D;Bose Jr, H R
• 通讯作者: Bose Jr, H R

The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB.

鸡 RelB 转录因子具有与哺乳动物 RelB 不同的反式激活序列和组织特异性表达模式。

• 发表时间: 2001-09
• 作者: Piffat, K A;Hrdlickova, R;Nehyba, J;Ikeda, T;Liss, A;Huang, S;Sif, S;Gilmore, T D;Bose Jr, H R
• 通讯作者: Bose Jr, H R

Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformation.

v-Rel 二聚化界面的突变分析揭示了 v-Rel 同二聚体在转化中的关键作用。

• 发表时间: 2002-05
• 作者: Liss, Andrew S;Bose Jr, Henry R
• 通讯作者: Bose Jr, Henry R

Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

pp40/I kappa B beta 与 rel/NF-kappa B 转录因子的直接关联：锚蛋白重复序列​​在抑制 DNA 结合活性中的作用。

• 发表时间: 1992-05-15
• 影响因子: 11.1
• 作者: Inoue, J;Kerr, L D;Rashid, D;Davis, N;Bose Jr, H R;Verma, I M
• 通讯作者: Verma, I M

Formation and rearrangement of disulfide bonds during maturation of the Sindbis virus E1 glycoprotein.

辛德毕斯病毒 E1 糖蛋白成熟过程中二硫键的形成和重排。

• 发表时间: 1994-02
• 作者: Mulvey, M;Brown, D T
• 通讯作者: Brown, D T