FUNCTIONALIZATION OF SILICONE RUBBER: PLASMA TREATMENT & SELF ASSEMBLY

硅橡胶的功能化：等离子处理

• 批准号: 6345045
• 负责人: K LEACH
• 金额: $ 1.35万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6345045
• 关键词: Mammalia; bioengineering /biomedical engineering; biological products; biomaterials; biomedical resource; health care; medical rehabilitation related tag; prosthesis; technology /technique

The goal of the project is to engineer the surface of poly(dimethylsiloxane) (PDMS) with a self-assembled monolayer (SAM) which terminates in a specific peptide or protein to which cells can directly attach and/or respond. The project will involve the development of necessary chemical reactions to modify the surface of the PDMS, with surface characterization after each step in the synthesis of the engineered surface. Once the desired surface has been developed, cultured cells will be grown on it and their attachment/response monitored. The effects of peptide/protein density on cell response will be examined as well.

该项目的目标是设计表面 具有自组装单层 (SAM) 的聚二甲基硅氧烷 (PDMS) 它终止于特定的肽或蛋白质，细胞可以 直接附加和/或响应。 该项目将涉及 发展必要的化学反应来改变表面 PDMS，在每个步骤后进行表面表征 工程表面的合成。 一旦获得所需的表面 开发完成后，培养细胞将在其上生长，并且它们的 监控附件/响应。 肽/蛋白质密度的影响 还将检查细胞反应。