BIVISTA: multi-modality imaging for improving surgical intervention

BIVISTA：用于改善手术干预的多模态成像

• 批准号: ST/M007820/1
• 负责人: John Lees
• 金额: $ 33.59万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FM007820%2F1
• 关键词: BIVISTA; multi; modality; imaging; improving

Major cancers such as pancreatic and breast cancer (worldwide incidence of over 277,000 and 1,383,000 respectively) rely on surgical intervention. The challenge is to reduce the mortality rate for these and other types of cancer through interventional imaging techniques that can assist clinicians and surgeons at the time of operation. Clinical diagnosis forms the basis for improved patient management and we propose that high quality imaging at the point of care will contribute to better diagnosis and treatment outcomes for patients.Gamma cameras are used routinely in many areas of medicine to image different tissue types and processes using radioactive 'tracer' compounds injected into the patient. The resulting images are of great value to the clinician in the staging and treatment of a variety of conditions. The combination of multi-spectral imaging, inherent in the BIVISTA system, will improve diagnosis and hence treatment management in a wide variety of cancers and other diseases. A patent application has been filed on the BIVISTA concept. The advantages of the BIVISTA versus larger-field gamma cameras include: Uniquely combines gamma and optical imaging Much higher resolution which allows imaging of smaller areas of tissue or the study of other processes such as lymph drainage Compact and mobile device offering real time imaging that can be used in a variety of environments, for example at the bedside and in the operating theatre. Multi-modality imaging: simultaneous optical and gamma ray and the ability to map fluorescence markers; an emerging technology in surgical practice. High spatial resolution information of 3D distribution of activity within the patientBIVISTA will deliver significant healthcare benefits to a range of patients.

胰腺癌和乳腺癌等主要癌症（全球发病率分别超过 277,000 例和 1,383,000 例）依赖于手术干预。面临的挑战是通过介入成像技术降低这些和其他类型癌症的死亡率，这些技术可以在手术时为临床医生和外科医生提供帮助。临床诊断是改善患者管理的基础，我们建议护理点的高质量成像将有助于为患者提供更好的诊断和治疗结果。伽马相机在许多医学领域中被常规使用，以使用不同的组织类型和过程进行成像将放射性“示踪剂”化合物注射到患者体内。生成的图像对于临床医生对各种病症的分期和治疗具有重要价值。 BIVISTA 系统固有的多光谱成像组合将改善多种癌症和其他疾病的诊断，从而改善治疗管理。 BIVISTA 概念已提交专利申请。与大视场伽马相机相比，BIVISTA 的优势包括： 独特地将伽马成像和光学成像结合在一起 分辨率更高，可以对较小的组织区域进行成像或研究淋巴引流等其他过程 紧凑型移动设备，提供实时成像，可以可用于各种环境，例如床边和手术室。多模态成像：同步光学和伽马射线以及绘制荧光标记的能力；外科实践中的一项新兴技术。 患者体内活动 3D 分布的高空间分辨率信息BIVISTA 将为一系列患者带来显着的医疗保健益处。

项目成果

Quantitative investigation of a novel small field of view hybrid gamma camera (HGC) capability for sentinel lymph node detection.

• DOI: 10.1259/bjr.20160435
• 发表时间: 2016-10
• 期刊: The British journal of radiology
• 作者: Alqahtani MS;Lees JE;Bugby SL;Jambi LK;Perkins AC
• 通讯作者: Perkins AC

Portable hybrid gamma-near-infrared fluorescence imaging

便携式混合伽马近红外荧光成像

• 发表时间: 2016
• 期刊: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
• 影响因子: 9.1
• 作者: Bugby S. L.

Design and implementation of a prototype head and neck phantom for the performance evaluation of gamma imaging systems.

• DOI: 10.1186/s40658-017-0186-3
• 发表时间: 2017-12
• 期刊: EJNMMI physics
• 影响因子: 4
• 作者: Alqahtani MS;Lees JE;Bugby SL;Samara-Ratna P;Ng AH;Perkins AC
• 通讯作者: Perkins AC

Energy-loss correction in charge sharing events for improved performance of pixellated compound semiconductors

• DOI: 10.1016/j.nima.2019.06.017
• 发表时间: 2019-10-01
• 期刊: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
• 影响因子: 1.4
• 作者: Bugby, S. L.;Koch-Mehrin, K. A.;Lees, J. E.
• 通讯作者: Lees, J. E.

Lymphoscintigraphic imaging study for quantitative evaluation of a small field of view (SFOV) gamma camera

• DOI: 10.1088/1748-0221/10/07/p07011
• 发表时间: 2015-07-01
• 期刊: JOURNAL OF INSTRUMENTATION
• 影响因子: 1.3
• 作者: Alqahtani, M. S.;Lees, J. E.;Perkins, A. C.
• 通讯作者: Perkins, A. C.