fMRI and Sports-Related Concussion

fMRI 和运动相关脑震荡

• 批准号: 6422928
• 负责人: Donald W. Marion
• 金额: $ 54.63万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6422928
• 关键词: adolescence (12-20); age difference; bioimaging /biomedical imaging; brain disorder diagnosis; brain imaging /visualization /scanning; brain injury; cognition; diagnosis design /evaluation; functional magnetic resonance imaging; gender difference; human subject; neuropsychological tests; outcomes research; patient oriented research; prognosis; sports medicine; young adult human (21-34)

DESCRIPTION (provided by applicant) Participants in organized sports-particularly football, hockey, and soccer-are at increased risk for sustaining one, and often multiple, concussions. Not only can multiple concussions cause long-term or permanent neurologic dysfunction, but there is evidence that athletes who suffer a second concussion before they have fully recovered from the first, are vulnerable to acute, severe brain swelling or death. However, there are no reliable standards for determining when an athlete can safely return to play after a concussion nor whether different criteria are needed depending on their age or gender. Such guidelines await elucidation of the pathophysiology and long-term effects of concussion, which are poorly understood. Current standards of care vary widely and are based on subjective experiences. They do not utilize physiological or neurocognitive measures. Two years ago, we developed a battery of neurocognitive tests (ImPACT) that assesses memory and attention, the two most common cognitive functions impaired by concussion. We have field tested ImPACT and found that this battery accurately reflects the onset and resolution of concussion-induced symptoms. During the next 5 years, we plan to use functional MRI (fMRI) to study 200 high school and college athletes who have suffered a concussion, in order to characterize post-concussive abnormalities in brain activation patterns. We will correlate changes in fMRI activation patterns with changes detected using a conventional test of working memory (N-Back), and also with the ImPACT battery. Using this paradigm, we will measure the effects of single vs. multiple concussions. The influences of age and gender on these abnormalities will be determined. Finally, we will assess how well changes in fMRI activation patterns, symptoms of concussion, and objective cognitive abnormalities correlate with each other and with academic performance 3 and 6 months after injury. We expect the results of this study to provide a physiologic and anatomic underpinning for the cognitive deficits observed after one or more concussions in different at-risk groups. Such information should enable the development of better guidelines for return to play, school, or work. The results of this study also will help determine which medications or other therapies are most likely to benefit victims of concussion in subsequent therapeutic trials.

描述（由申请人提供） 参加有组织的体育局部足球，曲棍球和足球比赛的参与者 持续脑震荡的风险增加。不仅 多次脑震荡会引起长期或永久神经功能障碍， 但是有证据表明，在他们之前遭受第二次脑震荡的运动员 从第一个完全恢复了，容易受到急性，严重的大脑的影响 肿胀或死亡。但是，没有可靠的标准来确定 当运动员可以在脑震荡之后安全地返回比赛时 根据其年龄或性别，需要不同的标准。这样的准则 等待病理生理学和脑震荡的长期影响， 这是很熟悉的。目前的护理标准差异很大，并且 基于主观经验。他们不利用生理或 神经认知措施。两年前，我们开发了一个电池 评估记忆和注意力的神经认知测试（影响），两者最多 脑震荡损害的常见认知功能。我们有现场测试的影响 并发现该电池准确反映了 脑震荡引起的症状。在接下来的5年中，我们计划使用功能 MRI（fMRI）学习200名高中和大学运动员 脑震荡，以表征大脑的脑震荡异常 激活模式。我们将将fMRI激活模式的变化与 使用常规的工作记忆测试（n-back）检测到的更改，还 带有冲击电池。使用此范式，我们将测量 单一与多个脑震荡。年龄和性别对这些的影响 将确定异常。最后，我们将评估变化的变化 fMRI激活模式，脑震荡症状和客观认知 异常彼此相关，并且与学业表现3和6相关 受伤几个月后。我们希望这项研究的结果能够提供 在观察到的认知缺陷之后的生理和解剖学基础 不同风险组中的一个或多个脑震荡。这样的信息应该 启用更好的指导原则以返回比赛，学校或 工作。这项研究的结果还将有助于确定哪些药物或 其他疗法最有可能在随后的脑震荡受害者中受益 治疗试验。