MELANOMA CONTROL FOR SIBLING OF MELANOMA PATIENTS

黑色素瘤患者兄弟姐妹的黑色素瘤控制

• 批准号: 6350259
• 负责人: BARBARA A GILCHREST
• 金额: $ 34.51万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-10 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6350259
• 关键词: cancer information system; cancer risk; clinical research; counseling; disease /disorder proneness /risk; health behavior; human subject; interview; melanoma; siblings

DESCRIPTION: With low cost screening and preventive procedures readily available, no one should die of cutaneous melanoma. Promoting melanoma control for at risk populations through regular skin cancer screening and sun protection practices should counter this modern cancer epidemic. Siblings (and other first-degree relatives) of melanoma patients have a two - eight fold elevated relative risk of developing melanoma themselves but have suboptimal knowledge of their risk and limited practice of screening and prevention measures. To date, no intervention protocols have targeted this high risk sibling group, a population estimated to be up to three-quarters million or more Americans. The investigators propose a randomized trial testing personalized telephone counseling intervention support and screening (PERTCISS) that delivers melanoma risk information to siblings and promotes screening and prevention practices. They propose to intervene at a time of a new diagnosis of melanoma in a family member, capitalizing on this teachable moment to reach siblings. They will randomize 450 adult siblings (New England residents) of newly diagnosed melanoma patients to PERTCISS or standard care (SC). The specific aims are to determine, in siblings, the impact of PERTCISS compared to SC on melanoma screening and prevention practices, as well as the knowledge and attitudes that mediate and motivate these practices. They hypothesize that, compared to those in SC, siblings randomized to PERTCISS will demonstrate: 1) Higher levels of three practices: a) physician skin cancer screening examinations, b) skin self-examination for melanoma, c) sun protection practices; and 2) Higher levels of knowledge about melanoma risk and improved attitudes about early detection and prevention.

描述： 易于进行低成本筛查和预防程序 如果可用的话，没有人会死于皮肤黑色素瘤。 促进黑色素瘤 通过定期皮肤癌筛查来控制高危人群 防晒措施应该能够对抗这种现代癌症的流行。 黑色素瘤患者的兄弟姐妹（和其他一级亲属）有两个 - 本身患黑色素瘤的相对风险增加八倍，但是 对自己的风险了解不够，筛查实践有限 及预防措施。 迄今为止，还没有针对任何干预方案 这个高风险的兄弟群体，人口估计高达 四分之三或更多的美国人。 研究人员提出了一项随机试验来测试个性化电话 咨询干预支持和筛查 (PERTCISS) 向兄弟姐妹提供黑色素瘤风险信息并促进筛查和预防 做法。 他们建议在出现新的诊断时进行干预 家庭成员患有黑色素瘤，利用这个受教育的时刻来达到 兄弟姐妹。 他们将随机抽取 450 名成年兄弟姐妹（新英格兰居民） 新诊断的黑色素瘤患者接受 PETCISS 或标准护理 (SC)。 具体目标是确定 PETCISS 对兄弟姐妹的影响 与 SC 在黑色素瘤筛查和预防实践方面的比较，以及 调解和激励这些实践的知识和态度。 他们 假设与 SC 中的兄弟姐妹相比，随机分配到 PETCISS 的兄弟姐妹 将展示： 1) 三种更高水平的实践： a) 医师皮肤 癌症筛查检查，b) 皮肤自我检查是否有黑色素瘤，c) 阳光 保护措施； 2) 关于黑色素瘤风险的更高水平的了解 并改善对早期发现和预防的态度。