METABOLIC BASIS OF CONJUGATED DIENES TOXICITY

共轭二烯毒性的代谢基础

• 批准号: 6309151
• 负责人: Adnan A. Elfarra
• 金额: $ 0.75万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-15 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6309151
• 关键词: Mammalia; biological products; biomedical resource; drug adverse effect; environmental toxicology; hematology; neoplasm /cancer; nuclear magnetic resonance spectroscopy; respiratory system

The broad objectives of the proposed research are to elucidate pathways of metabolic activation and detoxification of conjugated dienes, and to characterize the biochemical and chemical mechanisms by which conjugated dienes exert toxicological effects. Current research involves characterization by DNA and hemoglobin adducts and confirmation of the synthesis of chemical compounds. This information is needed in order to understand the biochemical basis of target-organ selectivity and species variability. (NIH ES 06841).

拟议研究的主要目标是阐明 结合物的代谢激活和解毒途径 二烯，并通过以下方式表征生化和化学机制 其中共轭二烯发挥毒理学作用。 目前的研究 涉及 DNA 和血红蛋白加合物的表征 化合物合成的确认。 此信息 为了了解靶器官的生化基础，需要 选择性和物种变异性。 （NIH ES 06841）。