GROWTH CONE ACTIVITY AND NEURONAL PLASTICITY

生长锥活性和神经元可塑性

• 批准号: 6301899
• 负责人: CHUN-FANG WU
• 金额: $ 16.82万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301899
• 关键词: Drosophilidae; cell adhesion; cell adhesion molecules; cell biology; cell growth regulation; cell motility; cyclic AMP; cytoskeleton; enzyme activity; growth cones; membrane activity; membrane proteins; mutant; neural plasticity; neurogenesis; neurogenetics; neuromuscular junction; neurons; neurophysiology; potassium channel; protein kinase C; protein structure function; second messengers; sodium channel; tissue /cell culture

This proposal seeks to characterize the cellular mechanisms underlying neuronal development and plasticity in Drosophila. It investigates the roles of second messenger systems, membrane excitability, membrane cycling, and cell adhesion, using methods of genetics, physiology, and cell biology. The proposal addresses a wide variety of issues relating to neuronal development and plasticity. It contains 9 specific aims, and the principal issues addressed are: 1) the role of second messenger systems in organizing the neuronal cytoskeleton and in the physiology of the neuromuscular junction; 2) the influence of nerve excitability and activity on cytoskeletal organization in cultured neurons and flight muscles; 3) the role of membrane vesicle proteins in regulating the addition of new membranes in neuronal development (e.g. as reflected in growth cone formation and neurite growth rates); 4) the role of the cytoplasmic tyrosine kinase abl and related proteins in cytoskeletal organization and neuronal adhesion.

该建议旨在表征细胞机制 果蝇的基本神经元发展和可塑性。 它 调查第二质商系统，膜的角色 兴奋性，膜循环和细胞粘附，使用的方法 遗传学，生理和细胞生物学。 该提议解决了一个范围 与神经元发展和可塑性有关的各种问题。 它 包含9个具体目标，所解决的主要问题是：1） 第二信使系统在组织神经元中的作用 细胞骨架和神经肌肉结的生理学； 2） 神经兴奋性和活性对细胞骨架的影响 培养的神经元和飞行肌肉的组织； 3） 膜囊泡蛋白在调节添加新的方面 神经元发育中的膜（例如，在生长锥中反映 形成和神经突的生长速率）； 4）细胞质的作用 酪氨酸激酶ABL和细胞骨架组织中相关蛋白 和神经元粘附。