PRECLINICAL TOXICOLOGY & PHARMACOLOGY OF DRUGS DEVELOPED

临床前毒理学

• 批准号: 6351926
• 负责人: NANCY A. TURNER
• 金额: $ 20万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-15 至 2003-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6351926
• 关键词: AIDS therapy; Rodentias; antiAIDS agent; antineoplastics; antiviral agents; dogs; dosage; drug screening /evaluation; mass spectrometry; neoplasm /cancer chemotherapy; nonhuman therapy evaluation; nuclear magnetic resonance spectroscopy; pharmacokinetics; pharmacology; toxicology

项目成果

Preclinical pharmacology of the novel antitumor agent adaphostin, a tyrphostin analog that inhibits bcr/abl.

新型抗肿瘤药物adaphostin（一种抑制 bcr/abl 的酪氨酸磷酸酶类似物）的临床前药理学。

• DOI: 10.1007/s00280-005-0094-4
• 发表时间: 2006
• 期刊: Cancer chemotherapy and pharmacology
• 影响因子: 3
• 作者: Li,Mao;Wang,Hui;Hill,DonaldL;Stinson,Sherman;Veley,Karen;Grossi,Irma;Peggins,James;Covey,JosephM;Zhang,Ruiwen
• 通讯作者: Zhang,Ruiwen

Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist.

整合体内和体外方法来表征 Antalarmin（一种促肾上腺皮质激素释放激素受体拮抗剂）的毒性。

• DOI: 10.1016/j.tox.2008.03.002
• 发表时间: 2008
• 期刊: Toxicology
• 影响因子: 4.5
• 作者: Horn,ThomasL;Harder,JBrooks;Johnson,WilliamD;Curry,PatrickT;Parchment,RalphE;Morrissey,RobertL;Mellick,PaulW;Calis,KarimA;Gold,PhilipW;Rice,KennerC;Contoreggi,Carlo;Charney,DennisS;Cizza,Giovanni;Glaze,ElizabethR;To
• 通讯作者: To

Liquid chromatography-electrospray tandem mass spectrometric assay suitable for quantitation of halofuginone in plasma.

液相色谱-电喷雾串联质谱测定法适用于血浆中卤常酮的定量。

• DOI: 10.1016/j.jchromb.2004.07.010
• 发表时间: 2004
• 期刊: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
• 作者: Parise,RobertA;Sparrow,BarneyR;Merrill,JohnW;Grossi,IrmaM;Covey,JosephM;Peggins,JamesO;Egorin,MerrillJ
• 通讯作者: Egorin,MerrillJ