Core--Natural Products

核心--天然产物

• 批准号: 6357129
• 负责人: ABIMAEL D RODRIGUEZ
• 金额: $ 37.6万
• 依托单位: UNIVERSIDAD CENTRAL DEL CARIBE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6357129
• 关键词: animal extract; biological products; biomedical facility; chemical synthesis; conformation; coral; diterpenes; marine biology; plant extracts

Since cembranoids are not commercially available, it is necessary to obtain them from their natural sources: soft corals found in the tropical seas around Puerto Rico, or from tobacco. The Natural Products Core is a unique CMBN facility that will became a part of the SNRP to provide the cembranoids needed in Projects 1 and 2. This core will organize diving expeditions for collections of specimens, will isolate the compounds to high purity, prepare custom-tailored synthetic analogues, determine their molecular structures, and calculates energy-minimized three-dimensional conformations.

由于木偶植物不可商购，因此有必要从其自然来源获取：在波多黎各周围的热带海洋中发现的软珊瑚，或者是从烟草中获得的。天然产品核心是一个独特的CMBN设施，它将成为SNRP的一部分，以提供项目1和2中所需的cembranoid。该核心将组织潜水探险，以集中标本，将化合物隔离到高纯度，制备定制的尾能合成类似物，确定其分子结构，并确定其分子结构，并确定其分子和钙化的三二维。