PHYSIOLOGY AND GENETICS OF OBESITY

肥胖的生理学和遗传学

• 批准号: 6108022
• 负责人: Jack ADAM Yanovski
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6108022
• 关键词: African American; adipose tissue; adrenocorticotropic hormone; basal metabolism; beta adrenergic receptor; bioenergetics; body composition; caucasian American; child (0-11); clinical research; corticotropin releasing factor; disease /disorder proneness /risk; epidemiology; genetics; glucose metabolism; glucose tolerance test; health behavior; human puberty; human subject; insulin sensitivity /resistance; leptin; lipid metabolism; longitudinal human study; noninsulin dependent diabetes mellitus; obesity; racial /ethnic difference

Substantial evidence suggests that risk factors and therapeutic approaches derived from the study of Caucasians may not be accurate or effective when applied to individuals of differing ethnicity or race. Many minority populations in the U.S., including African American women, have a markedly increased risk from obesity, diabetes mellitus, hypertension, cardiovascular disease, and mortality. This unit investigates the genetic, physiologic, metabolic, and behavioral factors involved in determining weight gain and weight loss in minority populations. This unit also investigates the etiology and treatment of obesity in children with obesity. Progress has been made in our current studies of logitudinal studies of body composition, energy expenditure, leptin, uncoupling proteins, insulin sensitivity, and glucose disposal, which seek to characterize the timing and nature of factors that may contribute to the prevalence of obesity and its complications. These studies will aid in the rational development of treatments for, and programs for the prevention of, obesity.

大量证据表明危险因素和治疗 来自白种人研究的方法可能不准确或 适用于不同民族或种族的个人时有效。 美国的许多少数民族人口，包括非裔美国妇女， 肥胖、糖尿病的风险显着增加， 高血压、心血管疾病和死亡率。 本单位 研究遗传、生理、代谢和行为因素 参与确定少数人的体重增加和体重减轻 人口。 该单元还研究了病因和治疗 肥胖儿童的肥胖。 我们目前的纵向研究取得了进展 身体成分、能量消耗、瘦素、解偶联蛋白、 胰岛素敏感性和葡萄糖处理，旨在表征 可能导致流行病流行的因素的时间和性质 肥胖及其并发症。 这些研究将有助于理性地 开发治疗方法和预防方案， 肥胖。