Neuroendocrine Mechanisms of Stress Buffering

压力缓冲的神经内分泌机制

• 批准号: 6999098
• 负责人: JASON E DAVIS
• 金额: $ 4.4万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-11 至 2007-08-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999098
• 关键词: adipose tissue; adrenocorticotropic hormone; animal population study; behavioral /social science research tag; corticosteroid receptors; corticosterone; corticotropin releasing factor; environmental stressor; ethology; hippocampus; hypothalamic pituitary adrenal axis; in situ hybridization; liver metabolism; male; muscle metabolism; neocortex; neuroendocrine system; postdoctoral investigator; reproduction; sex behavior; songbirds; species difference; stress

DESCRIPTION (provided by applicant): The proposed study will examine the neurological and endocrine mechanisms supporting environmentally adaptive buffering of stress induced behavioral and physiological alterations in two subspecies of white-crowned sparrows. These populations are of special interest because several previous studies have revealed substantial differences between them in terms of both their behavioral and hormonal responses to stress across the breeding season. The proposed study will search for differences between these subspecies during the early and late phases of the breeding season in relation to glucocorticoid and mineralocorticoid receptors in areas of the brain including the hippocampus, hypothalamus, and neocortex, as well as in peripheral tissue. In addition, we will also compare these two subspecies in terms of the sensitivity of corticosterone response to ACTH, AVT, CRF, and MT during both the early and late breeding season. This study will provide insight into the location and function of mechanisms enabling stress response buffering, as well as a better understanding of the flexibility of such adaptations.

描述（由申请人提供）：拟议的研究将检查支持白冠麻雀两个亚种应激引起的行为和生理变化的环境适应性缓冲的神经和内分泌机制。这些种群特别令人感兴趣，因为之前的几项研究表明，它们在整个繁殖季节对压力的行为和激素反应方面存在显着差异。拟议的研究将寻找这些亚种在繁殖季节的早期和晚期阶段与大脑区域（包括海马体、下丘脑和新皮质）以及周围组织中糖皮质激素和盐皮质激素受体的差异。此外，我们还将比较这两个亚种在繁殖季节早期和晚期皮质酮对ACTH、AVT、CRF和MT反应的敏感性。这项研究将深入了解压力反应缓冲机制的位置和功能，并更好地理解这种适应的灵活性。