A NOVEL TISSUE EQUIVALENT PHANTOM FOR HADRON THERAPY

用于强子治疗的新型组织等效模型

• 批准号: ST/J000698/1
• 负责人: Gianluigi Casse
• 金额: $ 15.14万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FJ000698%2F1
• 关键词: NOVEL; TISSUE; EQUIVALENT; PHANTOM; HADRON

A thin silicon sensor will be integrated in a mechanical system for scanning through a tissue equivalent liquid phantom for providing extremely accurate information on the dose deposited by a hadron therapy beam as a function of depth into the phantom and on the position in the plane perpendicular to the beam axis. This will allow a precise knowledge of the dose delivered to the patient (3d dose mapping) with unprecedented spatial resolution and speed. The dose deposited in depth by a hadron therapy beam in the human body follows a typical distribution that terminates with the high energy release called Bragg peak at the end of travel. This high energy deposition is exploited to maximise the effect to the cancer while giving limited amage to the surrounding helthy tissue. The accurate knowledge of the energy deposited by the beam is key to planning the treatment on individual patients. Also, the online monitoring of the Bragg peak position stability during treatment is essential for the success of the treatment.Thanks to the fast response of silicon detectors, the Bragg peak scan will provide real-time information to the operators on the dose to be released by the therapy beam in the target and surrounding tissue. This phantom makes use of a thinned silicon detector to enhance the accuracy of the scan. The precision of the reconstructed profiles can be selected to be as fine as 10 microns (this accuracy comes without cost or hardware complexity penalties). This instrument makes use of a single sensitive element (the silicon detector) moved by a precision motor in axis with the therapy beam. The energy deposition of the beam is continuously measured by the sensor while moved from the entrance point of the phantom to the back end. The beam is stopped within the phantom volume and the scan delivers the energy deposition profile with great accuracy and in real time. This instrument would represent a significant improvement with respect to existing phantoms because of its high spatial resolution and real time response. The precision would prove very valuable at the planning stage of the treatment and the speed for real-time feedback. It could be used at any hadron therapy centre alone or in combination with other existing beam monitoring equipment.

薄硅传感器将集成在机械系统中，以通过组织等效的液体幻影扫描，以提供对强子治疗束沉积的剂量的非常准确的信息，这是深度向幻影的函数，并在垂直于光束轴的平面位置上的位置。这将允许对以空前的空间分辨率和速度交付给患者的剂量（3D剂量映射）的精确知识。人体中的强子治疗束深入沉积的剂量遵循典型的分布，该分布在行进结束时以高能量释放称为Bragg Peak终止。利用这种高能量沉积以最大程度地提高癌症的影响，同时对周围的赫尔西组织有限。光束沉积的能量的准确了解是计划对个别患者进行治疗的关键。同样，在治疗过程中对Bragg峰位置稳定性的在线监测对于治疗的成功至关重要。感谢硅探测器的快速响应，Bragg Peak扫描将向操作员提供实时信息，该剂量将由治疗束在目标和周围组织中释放的剂量。该幻影利用稀薄的硅检测器来提高扫描的准确性。可以选择重建的配置文件的精度与10微米一样好（此精度无需成本或硬件复杂性惩罚）。该仪器利用一个敏感元件（硅探测器）由轴上的精确电动机和治疗束移动。梁的能量沉积是通过传感器连续测量的，同时从幻影的入口处移动到后端。光束在幻影体积内停止，扫描以极高的准确性和实时提供能量沉积曲线。由于其高空间分辨率和实时响应，该仪器将在现有幻象方面取得重大改进。精度将在治疗的计划阶段和实时反馈的速度中非常有价值。它可以单独在任何强子治疗中心使用，也可以与其他现有的梁监测设备结合使用。