AGE RELATED NON DISJUNCTION IN HUMAN OOCYTES

人类卵细胞中与年龄相关的不分离

• 批准号: 6305450
• 负责人: Patricia Hunt
• 金额: $ 1.92万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305450
• 关键词: age at pregnancy; age difference; biopsy; case history; clinical research; egg /ovum; human subject; meiosis; nondisjunction

Informatics only project - Data base design and analysis support. The aim of this NIH funded research project is to mature human oocytes in vitro to study the effect of advanced maternal age on the meiotic process. It is well known that one type of chromosome abnormality, trisomy, is significantly affected by the age of the woman. We are studying in vitro maturation and chromosome segregation in oocytes. Ovarian tissue specimens are retrieved from ovarian tissue removed in the course of surgery or through the NCI-funded Cooperative Human Tissue Network. We are currently collecting data from the patient information to form a collaborative data base. This data will include background information relating to reproductive, hormone, medical and medication, gynecologic surgical, smoking and drinking histories along with the surgical findings.

仅信息学项目 - 数据库设计和分析支持。 这个由美国国立卫生研究院资助的研究项目的目的是在体外使人类卵母细胞成熟，以研究高龄产妇对减数分裂过程的影响。 众所周知，一种染色体异常，即三体性，受女性年龄的影响显着。 我们正在研究卵母细胞的体外成熟和染色体分离。 卵巢组织标本取自手术过程中切除的卵巢组织或通过 NCI 资助的合作人体组织网络。我们目前正在从患者信息中收集数据以形成协作数据库。 这些数据将包括与生殖、激素、医疗和药物、妇科手术、吸烟和饮酒史以及手术结果相关的背景信息。