NIMH CHEMICAL SYNTHESIS PROGRAM

镍氢化学合成项目

基本信息

批准号：
6356869
负责人：
MARY J TANGA
金额：
$ 83.73万
依托单位：
SRI INTERNATIONAL
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-30 至 2001-09-29
项目状态：
已结题

项目摘要

The purpose of the NIMH Chemical Synthesis and Drug Supply Program is to synthesize and provide essential compounds that are unavailable from commercial sources to stimulate basic and clinical research relevant to mental health in areas such as the molecular pharmacology and signaling of CNS receptors, longitudinal studies to evaluate the molecular, biochemical, and behavioral actions of psychoactive compounds, and functional brain imaging in primates and humans. The objectives of the contract are to synthesize non-GMP compounds and GMP (Good Manufacturing Practices) compounds. Approximately 20% of the chemical syntheses may constitute proprietary compounds. Compounds synthesized under the contract could include, but are not limited to, psychoactive drugs, selective ligands for CNS receptor subtypes, ion channel modulators, signal transduction agents, peptides, small molecules, radiolabeled ligands for autoradiography or neuroimaging, chemicals, probes, and synthetic intermediates. The Contractor will store and maintain new and existing compounds in the NIMH Chemical Synthesis and Drug Supply Program Inventory, maintain an electronic database of compounds with analytical and technical information, distribute compounds to investigators, and maintain an electronic inventory of shipments. It is anticipated that synthesis requests will be submitted from a variety of sources including NIH- funded research programs, biotechnology companies, small pharmaceutical companies, or other sources. It is expected that the chemicals or drugs synthesized and distributed by this program will provide individual investigators with conceptual leads for basic and clinical studies of the neurobiology and treatment of mental disorders.

NIMH化学合成和药物供应计划的目的是合成并提供不可用的必需化合物从商业来源刺激基础和临床研究与分子药理学等领域的心理健康相关和中枢神经系统受体的信号传导，纵向研究以评估精神活性的分子，生化和行为作用灵长类动物和人类中的化合物和功能性脑成像。这合同的目标是合成非GMP化合物，并 GMP（良好的制造实践）化合物。大约20％化学合成可能构成专有化合物。根据合同合成的化合物可能包括但不包括限于CNS受体的精神活性药物，选择性配体亚型，离子通道调节剂，信号转导剂，肽，小分子，放射标记的配体进行放射自显影或神经影像，化学，探针和合成中间体。这承包商将存储并维护新的和现有的化合物 NIMH化学合成和药物供应计划库存，维护具有分析和技术的化合物的电子数据库信息，向调查人员分发化合物，并维护电子库存。预计合成请求将从多种来源提交，包括NIH- 资助的研究计划，生物技术公司，小型制药公司或其他来源。期望该程序合成和分发的化学药品或药物将为个人调查人员提供基本和神经生物学和心理治疗的临床研究疾病。