Synthesis of Polynuclear Aromatic Hydroca

多核芳烃的合成

• 批准号: 2651052
• 负责人: MARY J TANGA
• 金额: $ 28.68万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-25 至 2001-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2651052
• 关键词: benzopyrenes; biomarker; carbopolycyclic compound; chemical addition; chemical carcinogen; chemical carcinogenesis; chemical synthesis; mutagens; nitrosamines

The objective of this contract is to synthesize highly purified, well- characterized compounds that may have utility in the biological processes involved in carcinogenesis. Some of the compounds bay be carcinogens e.g., nitrosamines such as the tobacco specific carcinogens NNN, NNK, or anabasine. Some may be metabolic intermediates e.g., benzo(a)pyrene~ 7,8 diol, which is an intermediate in the metabolic conversion of benzo(a)pyrene to the potent ultimate carcinogen benzo(a)pyrene 7, 8 diol 9,10 epoxide. Some compounds may have demonstrated high mutagenicity and have a known exposure to humans but carcinogenic data are lacking, e.g., fecapentaenes, heterocyclic amine food mutagens. Other compounds may serve as biomarkers of exposure such as PAH DNA or protein adducts.

该合同的目的是合成高度纯化，良好的 表征在生物过程中可能具有效用的化合物 参与致癌作用。 某些化合物湾是致癌物，例如 硝基胺，例如烟草特异性致癌物NNN，NNK或 阿纳巴斯。 有些可能是代谢中间体，例如苯并（a）pyrene〜7,8 Diol，是代谢转化率的中间体 苯并（a）pyrene到有效的终极致癌苯并（a）pyrene 7，8 diol 9,10环氧。某些化合物可能表现出高诱变性和 已知接触人类，但缺乏致癌数据，例如 繁殖体，杂环胺食物诱变剂。 其他化合物可能服务 作为暴露的生物标志物，例如PAH DNA或蛋白质加合物。