DHEA CAN ENHANCE SUCCESS OF SMOKING CESSATION PROGRAM

DHEA 可以提高戒烟计划的成功率

• 批准号: 6298343
• 负责人: FRANK SVEC
• 金额: $ 1.97万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298343
• 关键词: blood chemistry; clinical research; clinical trial phase I; dehydroepiandrosterone; female; hormone therapy; human subject; human therapy evaluation; pharmacokinetics; smoking cessation

The purpose of this study is to determine whether the hormone DHEA (dehydroepiandrosterone: a natural hormone produced in the adrenal glands of humans) makes it easier to stop smoking. Women who smoke have higher levels of DHEA in their serum. When they stop smoking, this level drops. There is some evidence that falling DHEA levels may cause problems. It is possible that by giving a person DHEA, it will be easier to stop smoking. This study is designed to evaluate how much DHEA a woman who does not smoke needs to take in order to attain the same level of DHEA in the blood of a woman who smokes. This will allow assessment of how much DHEA needs to be given to a person while they stop smoking in order to keep their serum DHEA level at the same level as while they were smoking.

这项研究的目的是确定激素DHEA是否 （脱氢表雄酮：肾上腺中产生的天然激素 人类的）使得停止吸烟变得更容易。吸烟的妇女更高 血清中的DHEA水平。当他们停止吸烟时，此水平会下降。 有证据表明，DHEA水平下降可能会导致问题。它 有可能给予一个人DHEA，更容易停止 吸烟。这项研究旨在评估一位女性的DHEA 为了达到相同水平的DHEA，不需要冒烟 在一个吸烟的女人的血液中。这将允许评估如何 一个人停止吸烟时需要给予很多DHEA 保持其血清DHEA水平与它们相同的水平 吸烟。