EFFECT OF MEALS ON SERUM DHEA

膳食对血清 DHEA 的影响

• 批准号: 6122092
• 负责人: FRANK SVEC
• 金额: $ 1.12万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-19 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122092
• 关键词: clearance rate; clinical research; clinical trials; dehydroepiandrosterone; eating; hormone biosynthesis; hormone regulation /control mechanism; human subject; insulin; nutrient interaction; nutrition related tag

DHEA is a hormone made in the adrenal gland that appears to protect people from heart attacks. At this time little is known about those factors that control the level of this hormone in the blood. One condition that stimulates the adrenal gland is the consumption of a meal. Hence, it was anticipated that when a person ate, his blood level of DHEA should rise. However, the Principal Investigator found in preliminary studies, that the level actually goes down with meals. Others have shown that insulin enhances the clearance (or removal) of DHEA from the serum. It is often reasoned that the decrease in serum DHEA is caused by the rise in insulin of a meal. The goal of this project is to test this hypothesis by monitoring the fall of DHEA and comparing it with the increase in insulin in response to a standard meal.

DHEA是一种在肾上腺中制造的激素，它似乎可以保护人们免受心脏病发作。 目前，那些控制血液中这种激素水平的因素知之甚少。 刺激肾上腺的一种疾病是食用一顿饭。 因此，预计当一个人吃饭时，他的DHEA血液水平应该升高。但是，首席研究人员在初步研究中发现，该水平实际上是随餐的降低的。 其他人则表明，胰岛素可增强血清中DHEA的清除（或去除）。 通常认为，血清DHEA的降低是由一顿饭的胰岛素增加引起的。 该项目的目的是通过监测DHEA的衰落并将​​其与响应标准餐的胰岛素增加来检验这一假设。