NEURAL MECHANISMS OF STIMULUS MEMORY AND HABIT FORMATION

刺激记忆和习惯形成的神经机制

• 批准号: 6290506
• 负责人: MORTIMER MISHKIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290506
• 关键词: Primates; caudate nucleus; entorhinal cortex; experimental brain lesion; frontal lobe /cortex; habits; memory; neural information processing; neuroanatomy; putamen; short term memory; thalamus; visual cortex; visual stimulus

The essential circuit for both item and associative stimulus recognition in any given sensory modality (or across modalities) consists of the relevant cortical sensory processing stream(s), the medial temporal periallocortex (i.e. parahippocampal, perirhinal, and entorhinal cortices), the ventromedial prefrontal cortex, and the magnocellular division of the medial dorsal nucleus of the thalamus. Associative recall, on the other hand, appears now to be organized hierarchically; thus, whereas context-free recall, or fact memory, also seems to depend primarily on the above basic memory circuit, context- rich recall, or event memory, seems to depend in addition on a higher- order circuit superimposed on the basic one and consisting of the hippocampus, mamillary body, anterior thalamic nuclei, and cingulate cortex. That item recognition at least does not depend on the higher- order memory circuit is supported by new evidence obtained in Jon (reported on initially in Science 277: 376-380, 1997) who has seemingly selective bilateral hippocampal pathology induced by a neonatal hypoxic/ischaemic insult. On standardized memory tests allowing quantitative assessment, Jons recognition scores were at or above the 50th percentile, whereas his recall scores fell at or below the 1st percentile. That associative recognition also does not depend on the higher-order memory circuit (but does require the basic circuit) is supported by new evidence obtained in monkeys. These new results indicate that the ability to form one-trial object-place associations is unaffected by selective, excitotoxic damage to the hippocampus, and yet is severely impaired by ablation of the underlying p - Single case, monkeys, recognition, recall, object-place association, hippocampus, parahippocampal cortex - Human Subjects

在任何给定的感觉方式（或跨模态）中项目和联想刺激识别的基本电路都由相关的皮质感觉处理流，内侧颞上图皮层（即parahippococapal，Peririrhinal和intorhinal Cortices），室外胞胎的分裂，以及植物的分裂，以及植物的分裂。丘脑。另一方面，联想召回现在似乎是在层次上组织的。因此，尽管无上下文的回忆或事实记忆似乎也主要取决于上述基本记忆电路，上下文 - 丰富的回忆或事件记忆似乎还取决于叠加在基本的较高电路上，并由海马体，乳房乳房，前体，thalamic thalamic nuclei和cickulate cortex组成。该项目的识别至少不取决于较高的记忆回路，由乔恩（Jon）获得的新证据支持（最初在科学中报道了277：376-380，1997），后者看似选择性双侧海马病理学是由新生儿低氧/缺血/缺血性疾病诱导的。在允许定量评估的标准记忆测试中，JONS识别分数处于或高于第50个百分位数，而他的召回分数则低于或以下是第一个百分点。该关联识别也不取决于高阶记忆电路（但确实需要基本电路），猴子在猴子中获得的新证据支持。这些新的结果表明，形成单审对象位置关联的能力不受选择性的，兴奋的毒性损害对海马的影响，但由于消融基础的P-单个病例，猴子，识别，识别，召回，对象 - 对象 - 对象，海马帕克群，人类的猴子，人类副标，人类识别，人类识别，人类识别，人类识别，人类识别，人类识别，人类识别，人类识别，人类识别，人为识别，人为识别。