FUNCTIONAL NEUROANATOMY OF FEAR CONDITIONING

恐惧调节的功能神经解剖学

• 批准号: 6139345
• 负责人: DAVID C KNIGHT
• 金额: $ 2.78万
• 依托单位: UNIVERSITY OF WISCONSIN MILWAUKEE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6139345
• 关键词: behavioral /social science research tag; conditioning; fear; human subject; learning; magnetic resonance imaging; neuroanatomy

The long term goal of this project is to improve our understanding of how neural systems in the human brain subserve aversive emotional states like fear and anxiety by assessing the brain metabolic activity of healthy volunteers with Functional Magnetic Resonance Imaging (fMRI). Specifically, this project will focus on the acquisition and performance of Pavlovian fear conditioning by assessing dynamic changes in regional activation during the learning process and when a fear response is expressed. These goals will be achieved with two experiments. In the first experiment, volunteers will be initially trained (acquisition) to fear a neutral stimulus. Then their memory for the previous training (performance) will be assessed. Functional and anatomical images will be obtained during both acquisition and performance phase. In the second experiment, volunteers will be differentially trained to fear one stimulus (Csplus) and not to fear a second stimulus (CS-). In this experiment, subjects will serve as their own control, and Probe trials will be used to make comparisons without UCS presentation. These experiments will answer questions about which neural structures are involved in learning and expression of conditional fear, will describe the temporal pattern of activation within these structures, will provide insights into how the involvement of various structures change as learning occurs and fear is expressed, and will comparisons with learning animal model systems. The data to be collected will substantially advance our understanding of neuroanatomical mechanisms of human fear and anxiety, and may directly contribute to improvements in the assessment and treatment of affective disorders.

该项目的长期目标是提高我们对 人脑中的神经系统如何促进厌恶情绪 通过评估大脑代谢活动来评估恐惧和焦虑等状态 健康志愿者进行功能磁共振成像 （功能磁共振成像）。 具体来说，该项目将重点关注收购和 通过评估动态巴甫洛夫恐惧调节的表现 学习过程中区域激活的变化以及当 表达了恐惧反应。 这些目标将通过两个 实验。 在第一个实验中，志愿者将接受初步培训 （收购）害怕中性刺激。 然后他们的记忆 将评估之前的培训（表现）。 功能性和 解剖图像将在采集和 表现阶段。 在第二个实验中，志愿者将 经过差别训练，害怕一种刺激（Csplus），而不害怕另一种刺激 第二刺激（CS-）。 在这个实验中，受试者将作为他们的 自己的对照，并将使用探针试验进行比较 没有 UCS 演示。 这些实验将回答问题 哪些神经结构参与学习和表达 有条件的恐惧，将描述激活的时间模式 在这些结构中，将提供有关如何参与的见解 随着学习的发生和恐惧的表达，各种结构的变化， 并将与学习动物模型系统进行比较。数据至 收集起来将大大增进我们对 人类恐惧和焦虑的神经解剖学机制，并且可能 直接有助于改善评估和治疗 情感障碍。