SALINE ENHANCED RADIOFREQUENCY ABLATION FOR LIVER TUMORS

肝脏肿瘤的盐水增强射频消融

• 批准号: 6072490
• 负责人: MICHAEL G CURLEY
• 金额: $ 47.54万
• 依托单位: THERMEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6072490
• 关键词: electrodes; heat; laboratory rabbit; liver neoplasms; neoplasm /cancer thermotherapy; radiowave radiation; saline; sound frequency; swine; technology /technique development

DESCRIPTION (Adapted from Applicant's Abstract): Liver cancer, especially colorectal cancer, is a significant health concern. In the United States, half of the 157,000 new cases of colorectal cancer will lead to metastases in the liver, which will lead to over 17,000 deaths. And while not as significant a health risk as colorectal metastasis, hepatocellular carcinoma is being diagnosed with increasing frequency. The current standard of practice for treating liver cancer is surgical resection, but only 10% of patients are eligible for this procedure. Thermal ablation using radiofrequency is a promising alternative therapy, but it can only treat small tumors. The applicants propose to continue development of a saline-enhanced radiofrequency ablation system for treating large liver tumors. The system uses radiofrequency energy to heat tissue, but this would be complimented with simultaneous injection of warm saline through the electrode and into the tissue The injected saline flows through the extracellular space and convects the thermal energy deep into the tissue. Consequently, it would be possible to treat significantly larger tumor volumes than previously possible. The technique has been reported to created thermal lesions whose volumes are 90 times as large as those created with conventional radiofrequency electrodes. The method would therefor enable percutaneous thermal ablation therapy to be used on larger tumors, greatly increasing the number of patients eligible for therapy. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：肝癌，尤其是 结直肠癌，是一个重大的健康问题。在美国，一半 157,000 例结直肠癌新病例中的 1 例将导致结肠癌转移 肝脏，这将导致超过 17,000 人死亡。虽然不那么重要 结直肠癌、肝细胞癌等健康风险 诊断频率不断增加。目前的实践标准 肝癌的治疗方法是手术切除，但只有10%的患者接受手术切除 符合此程序的资格。使用射频的热消融是一种 有前途的替代疗法，但它只能治疗小肿瘤。这 申请人提议继续开发盐水增强射频 用于治疗大型肝脏肿瘤的消融系统。该系统采用射频 能量来加热组织，但这将得到同时进行的补充 通过电极将温盐水注射到组织中 盐水流过细胞外空间并使热能对流 深入组织。因此，可以显着治疗 肿瘤体积比以前更大。该技术已被报道 创建热损伤，其体积是所创建热损伤的 90 倍 与传统的射频电极。该方法将因此能够 经皮热消融疗法可用于较大的肿瘤 增加符合治疗条件的患者数量。 拟议的商业应用：不可用