DEVELOPMENT OF A NON-INSTRUMENTED PROTHROMBIN TIME TEST

非仪器化凝血酶原时间测试的开发

• 批准号: 6317411
• 负责人: Wai Tak Law
• 金额: $ 11.22万
• 依托单位: PORTASCIENCE, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-05 至 2001-03-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6317411
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; consumable /disposable biomedical equipment; human tissue; material; prothrombin time; thromboplastin

Development of a disposable non-instrumented prothrombin time test (PF) for home use is proposed. Preliminary data using flow channels built with precision engineered fabric demonstrated the potential of the proposed test device. The end points of the flow of the blood samples stopped due to clotting were repeatable, easy to read, and there was correlation between PT observed and the bar length observed. A simple and accurate disposable device is potentially a powerful tool to help patient to monitor their PT at home weekly. We propose to further study, optimize, and develop a non-instrumented device that will he less expensive and more convenient for both the physician and patient to monitor PT values than instruments that are currently available. PROPOSED COMMERCIAL APPLICATION: There are more than 2 million patients in the U.S.A. alone that are taking oral anti-coagulation therapy, and need to monitor their PT weekly. The potential market for a use monitoring device is very large. The proposed device is expected to provide a simple, and accurate alternative to the current techniques.

建议开发一种家用的一次性非仪器凝血酶原时间测试（PF）。 使用精密工程织物构建的流道的初步数据证明了所提出的测试装置的潜力。因凝血而停止的血样的流动终点可重复、易于读取，并且观察到的PT和观察到的条长度之间存在相关性。简单而准确的一次性设备可能是帮助患者每周在家监测 PT 的强大工具。我们建议进一步研究、优化和开发一种非仪器设备，与目前可用的仪器相比，这种设备对医生和患者来说更便宜、更方便地监测 PT 值。拟议的商业应用：仅在美国就有超过 200 万患者正在接受口服抗凝治疗，并且需要每周监测他们的 PT。使用监控设备的潜在市场非常大。所提出的设备有望为当前技术提供简单而准确的替代方案。