RENOVATION OF THE ULLMANN ANIMAL UNIT

乌尔曼动物单元的翻新

• 批准号: 2558178
• 负责人: Diane J. GAERTNER
• 金额: $ 59.89万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-18 至 2001-05-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2558178
• 关键词: animal care; animal colony; biomedical equipment purchase; biomedical resource; building /facility design /renovation

In this revised submission, matching funds are requested to renovate the Ullmann Animal Unit of the Albert Einstein College of Medicine, a major biomedical research institution with more than 44 million dollars in PHS funding. The Ullmann Animal Unit of 16,400 net square feet includes the 10th and 11th floors of the Ullmann building and house approximately half of AECOM's research animals, supporting more than 60 investigators and most major research programs of the college. The objective are (1) to convert largely unused dog rooms to additional barrier rodent space and more flexible space, (2) to improve the control of airflow and formite- borne rodent pathogens in rooms and hallways, (3) to improve cage sanitization, (4) to remove heat and humidity generated by cage washing, (5) to better vent exhaust anesthetic gasses, (6) to control temperature for Xenopus frogs, (7) to remove windows from animal rooms, and (8) to increase housing for pathogen-free mice. These objectives will be met by a 4-part renovation plan. In Part A, six large rooms will be renovated to create two barrier rodent suites and two multi-species rooms. The barrier rodent suites will be used to re-derive and re-stock the Ullman Building with pathogen-free rodents. The multi-species rooms will flexibly house small numbers of dogs, pigs, or sheep. In Part B, the cage-wash will be expanded to store dirty cages, the antiquated tunnel and rack washers will be replaced and the room exhaust will be upgraded. A new fume hood will be installed to vent waste anesthetic gasses from a heavily-used procedure room. In Part C, in-room supplemental cooling and new caging will be purchased to permit optimal housing and natural breeding of Xenopus frogs by providing temperatures under 72 degrees F. In Part D, 120 windows in 31 animals rooms on two floors will be eliminated to permit photoperiod control and to increase energy efficiency. This set of 4 related renovations will permit much-needed expansion of pathogen-free housing for rodents, including increasing numbers of immunodeficient, transgenic and knock-out mice in both the Ullman and Chanin buildings. These renovations are urgently needed and will assure compliance with the USDA Animal Welfare Act and DHHS policies related to room temperatures, controlling lighting and ventilation, working conditions for animal caretakers. The renovations will also assist us in maintaining our AAALAC accreditation.

在此修订的提交中，要求匹配资金进行翻新 阿尔伯特·爱因斯坦医学院的乌尔曼动物部门，主要 生物医学研究机构拥有超过4400万美元的PHS 资金。 16,400平方英尺的Ullmann动物单元包括 Ullmann建筑物的10层和11层，房屋约一半 AECOM的研究动物，支持60多个研究人员 学院大多数主要的研究计划。目标是（1） 将大量未使用的狗室转换为其他障碍啮齿动物空间， 更灵活的空间，（2）改善气流和Formite-的控制 房间和走廊中传播的啮齿动物病原体，（3）改善笼子 消毒，（4）消除笼子清洗产生的热和湿度， （5）更好地排气耗尽麻醉气体，（6）控制温度 Xenopus蛙，（7）从动物室卸下窗户，（8）到 增加无病原体小鼠的外壳。这些目标将由 四部分的翻新计划。在A部分中，六个大房间将进行翻新为 创建两个障碍啮齿动物套房和两个多物种房间。障碍 啮齿动物套房将用于重新衍生并重新存储Ullman大楼 与无病原体啮齿动物。多物种房间将灵活地容纳 少数狗，猪或绵羊。在B部分中，笼子洗了 扩展到存储肮脏的笼子，过时的隧道和机架垫圈将 被更换，房间排气将升级。一个新的通风罩将是 安装以发泄垃圾麻醉气体，从严重使用的过程中 房间。在C部分中，室内补充冷却和新的笼子将是 购买以允许Xenopus蛙的最佳住房和天然育种 通过在72度以下的温度下提供温度。 将消除两层的动物房间，以允许光周期 控制和提高能源效率。这套4个相关 翻新将允许急需的无病原体外壳扩张 啮齿动物，包括越来越多的免疫缺陷，转基因和 Ullman和Chanin建筑物中的淘汰小鼠。这些翻新 迫切需要并确保遵守美国农业部动物 福利法和DHHS政策与室温有关，控制 照明和通风，动物看护人的工作条件。这 翻新也将有助于我们维持AAALAC认证。