STUDY OF ENDOMEMBRANES SYSTEMS OF GIARDIA

贾第鞭毛虫内膜系统的研究

• 批准号: 6282139
• 负责人: MARCIA ATTIAS
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282139
• 关键词: biomedical resource; computers; epidemiology; human tissue; infection; international health /scientific organization; microscopy; parasitism

This project is focused on the study of the endomembranes systems (the endoplasmic reticulum and peripheric vacuoles) of Giardia, a very primitive unicellular eukaryote. This study is part of a larger project on the endocytotic and intracellular trafficking and protein sorting processes in this organism. There is also interest in the study of the motor system of Giardia because by videomicroscopy we could see that the flagella moves as well as cell body. For this purpose we have collaborated with the NCMIR. Tomographic reconstructions have been performed on Giardia at the NCMIR in order to see the relationship between the endoplasmic reticulum and peripheric vacuoles. Several tomographc reconstructions were obtained while Dr. Attias visited the NCMIR in December, 1996. We have been tracing the outlines of the endoplasmic reticulum and the peripheric vacuoles using XVOXTRACE and have sent the completed reconstructions to Dr. Attias.

该项目的重点是对内膜系统的研究 （内质网和周围液泡）的贾第鞭毛虫，非常非常 原始单细胞真核生物。 这项研究是较大的一部分 关于内吞和细胞内贩运和蛋白质的项目 在此生物体中分类过程。 对 贾第鞭毛虫运动系统的研究是因为通过视频显微镜检查 可以看到鞭毛运动和细胞体移动。 为了这 目的我们与NCMIR合作。 层析成像 已按顺序在NCMIR上对贾迪亚进行了重建 查看内质网和 外围液泡。 获得了几个断层扫描的重建 阿蒂亚斯博士于1996年12月访问了NCMIR。我们一直 追踪内质网和周围的轮廓 使用XVoxTrace的液泡并发送了完整的重建 致阿蒂亚斯博士。