A Swiss army knife for aerosol composition - a community Chemical Ionisation Mass Spectrometry facility

用于气溶胶成分分析的瑞士军刀 - 社区化学电离质谱设施

• 批准号: NE/X006131/1
• 负责人: Hugh Coe
• 金额: $ 91.6万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FX006131%2F1
• 关键词: Swiss; army; knife; aerosol; composition

The capital asset is a next-generation community capability to measure atmospheric composition that can be used to address critical science and policy-related problems across the NERC Research and Innovation theme remits. Molecular compound identification is central to understanding many environmental processes. Advances in high performance mass spectrometry have developed rapidly but offline methods cannot capture dynamic processes owing to poor time resolution of the collected sample. Many current environmental challenges require rapid molecular detection and identification at high time resolution to understand highly dynamic processes. Recent advances now make this possible. Previous generations of instrument are expensive and complex to use, so they are only accessible to a few groups with the technological capability and infrastructure to support them. Further, ionisation schemes are often designed for detection of certain types of compounds and multiple instruments may be needed. This is costly and beyond the capabilities of many research groups. We propose a facility to deliver rapid detection and identification of a wide range of molecules with high sensitivity and specificity in both particle and gas phases in a single instrument and that can be applied to a wide range of atmospheric and environmental problems of pressing societal need.The asset comprises a chemical ionisation mass spectrometer with a novel suite of interchangeable inlets and able to sample molecules in particles and gases into a single high resolution instrument, simultaneously running multiple ionisation sources (none requiring a radioactive source, as is commonly the case). Co-designed with a broad user community represented by the investigators, a bespoke data collection and analysis software suite will be developed to service a range of standard operating procedures for target applications, enabling turnkey operation of the asset. This ease-of-use is key to the provision of the asset as a community resource. It will enable deployment at partner institutions without the resource for operation of the current generation of instruments and hence a much broader user base, for which a usage model will be developed (including a model for more advanced operation and delivery).By providing a multi-use integrated and easy to use facility for trace particle and gas characterisation, we will be able to rapidly rise to challenges associated with transition to Net Zero, to provide deep understanding of atmospheric challenges in the face of rapidly changing climate, the associated ecosystem responses, and a range of pressures arising from human activities. Environmental applications that the asset will make accessible include:Impacts of indoor and outdoor air quality on health: i) toxicological hazard ranking of air pollution sources, ii) health inequalities associated with differential exposure to indoor and outdoor pollutionAtmospheric chemical transformations: i) primary and secondary aerosol ageing, ii) formation and transformation of secondary organic and inorganic aerosols and precursors, iii) impacts of novel trace gas chemistrySurface - atmosphere exchange: i) quantification of terrestrial biogenic and anthropogenic PM and gas emission sources (e.g. ammonia, POA), ii) quantification of marine atmospheric processesPlant VOC production: i) roles in regulating multitrophic interaction and plant competition, ii) promoting defensive VOC production by crop plants or neighbouring 'barrier' plantsSubsurface VOC modulation: i) eco-evolutionary implications of interactions in the rhizosphere, ii) VOC emission control by microbial activity and organic matter decomposition in soil, iii) novel pathways to convert waste CO2 to useful products tracked by VOCs as markers..NERC and UKRI have made considerable investment in each area through the funding portfolio of our investigator team of leading researchers and across all NERC R&I themes.

资本资产是衡量大气组成的下一代社区能力，可用于解决NERC研究和创新主题的关键科学和与政策有关的问题。分子化合物识别对于理解许多环境过程至关重要。高性能质谱的进步已经迅速发展，但是由于收集的样品的时间分辨率差，离线方法无法捕获动态过程。当前的许多环境挑战需要在高时间分辨率下快速的分子检测和识别，以了解高度动态的过程。最近的进步使这成为可能。前几代仪器的使用既昂贵又复杂，因此只有几个具有技术能力和基础设施来支持它们的团体才能使用它们。此外，电离方案通常是设计用于检测某些类型化合物的设计，并且可能需要多种仪器。这是许多研究小组的昂贵，而且超出了许多研究小组的能力。我们提出了一种设施，以在单个仪器的粒子和气相中对各种分子进行快速检测和鉴定，并可以应用于紧迫的社会需求的各种大气和环境问题，资产构成了化学电离质谱仪，并构成了一个化学电离仪表，并具有透明的范围，以界定范围，并将其用于分类的新型套件，以分类为单位，以使分子的新型套件，使得分子的固定套件，并将其用于分子的分子，并将其构成分子的固定群体，并构成分子的固定群体，并将其构成对方案的固定群体，并构成了对方案的固定群体，并将其构成。同时运行多个电离源（通常不需要放射性源，就像通常情况下一样）。与调查人员代表的广泛用户社区共同设计，将开发一个定制的数据收集和分析软件套件，以服务目标应用程序的一系列标准操作程序，从而使资产的交钥匙运行。这种易用性是提供资产作为社区资源的关键。 It will enable deployment at partner institutions without the resource for operation of the current generation of instruments and hence a much broader user base, for which a usage model will be developed (including a model for more advanced operation and delivery).By providing a multi-use integrated and easy to use facility for trace particle and gas characterisation, we will be able to rapidly rise to challenges associated with transition to Net Zero, to provide deep understanding of atmospheric challenges in the face of rapidly changing climate, the相关的生态系统反应以及人类活动引起的一系列压力。该资产将使可及的环境应用包括：室内和室外空气质量对健康的影响：i）空气污染源的毒理危险等级排名，ii）与室内和室外污染不同的健康不平等相关的健康不平等：新型痕量气体化学表面表面的影响 - i）定量陆地生物源和人为PM和气体发射源（例如氨，POA），ii）海洋大气过程的定量量化海洋大气过程的定量：i）i）在调节多种繁殖互动和工厂竞争中的作用，ii）促进型号的作品，ii）trarbor of Voceer overs overs overs overs overs overs over overs of overing overs overs overs overs overs overs overs overs overs overs of over''''）跨根际相互作用的生态进化意义，ii）通过微生物活性和有机物分解的VOC发射控制，iii）将废物CO2转换为VOC作为标记的有用产品的新途径。.NERC和UKRI通过我们的研究人员的研究人员和跨各种研究人员的研究人员和跨各种研究人员的资助来对每个领域进行了相当大的投资。