GRANZYMES OF CYTOTOXIC LYMPHOCYTES

细胞毒性淋巴细胞颗粒酶

• 批准号: 6280194
• 负责人: Dorothy Hudig
• 金额: $ 0.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280194
• 关键词: biomedical resource; biotechnology; lymphatic system

Using the facilities of the Computer Graphics Laboratory, we are working on modelling the substrate binding sites of new granzyme serine proteases, based on the X-ray crystal structure of rat mast cell chymase II, another serine protease. Knowledge of potential substrates will allow them to be synthesized and tested to determine if the granzyme gene products are active enzymes. These proteases are in cytotoxic granules of killer cells and probably play critical roles in killing of virally infected cells and/or in signalling for inflammation.

使用计算机图形实验室的设施，我们是 致力于建模新颗粒酶的底物结合位点 丝氨酸蛋白酶，基于大鼠桅杆的X射线晶体结构 细胞芝士II，另一种丝氨酸蛋白酶。 潜力的知识 底物将允许它们合成和测试以确定 如果颗粒基因产物是活性酶。 这些蛋白酶是 在杀伤细胞的细胞毒性颗粒中，可能起关键作用 在杀死病毒感染的细胞和/或信号传导中 炎。