TUBERCULOSIS IN A MULTIETHNIC CITY POPULATION

多民族城市人口中的结核病

• 批准号: 6276938
• 负责人: MICHAEL MARMOR
• 金额: $ 2.03万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276938
• 关键词: HIV infections; Mycobacterium tuberculosis; adult human (21+); behavioral /social science research tag; chemoprevention; child (0-11); clinical research; clinical trials; disease /disorder proneness /risk; epidemiology; ethnic group; genetic strain; human subject; human therapy evaluation; intravenous drug abuse; microorganism disease chemotherapy; opportunistic infections; pathologic process; therapy compliance; tuberculosis; urban area

This protocol will determine the incidence of Mycobacterium tuberculosis (M tb) infection in HIV-infected and -uninfected injecting drug users (IDUs), sexual partners of IDUs, and children in contact with TB- infected adults. It will identify environmental and host risk factors for developing M tb infection; describe the natural history of M tb disease in children and adults; investigate the epidemiology of specific strains of M tb; evaluate the effect of M tb coinfection on the rate of progression of HIV disease; and investigate factors influencing compliance with tuberculosis prophylaxis and therapy. The lab was used for blood separation, ultracentrifugation, DNA isolation, ELISA, PCR, RNA analysis, and sample storage.

该方案将确定结核分枝杆菌的发生率 （M TB）感染HIV感染和未感染的注射吸毒者 （IDU），IDUS的性伴侣和与TB接触的孩子 感染的成年人。 它将确定环境和主机风险因素 用于发展M TB感染；描述M TB的自然历史 儿童和成人的疾病；研究特定的流行病学 M TB的菌株；评估M TB共感染对速率的影响 艾滋病毒疾病的进展；并调查影响的因素 遵守结核病预防和治疗。 实验室被使用 为了血液分离，超速离心，DNA隔离，ELISA，PCR， RNA分析和样品存储。