Core--Recruitment, epidemiology and biostatistics

核心--招募、流行病学和生物统计学

• 批准号: 6808339
• 负责人: MICHAEL MARMOR
• 金额: $ 24.22万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6808339
• 关键词: HIV infections; behavioral /social science research tag; biomedical facility; case history; clinical research; communicable disease transmission; health behavior; high risk behavior /lifestyle; human subject; interview; medical outreach /case finding; patient oriented research; statistics /biometry

This core will support the projects proposed herein by the expansion and maintenance of the high risk cohort of uninfected men and women, the development of an outreach program to recruit additional subjects with acute or early HIV infection, and facilitation of data collection across multiple sites. This Core will also extend the functions of the NYU CFAR Clinical Support Core in the provision of biostatistical and epidemiological analyses for all projects. The Core will identify persons with acute and early HIV infection to support the timely completion of each of the projects. Epidemiologic information will be accumulated on each subject to estimate the date and route of HIV infection, demographic characteristics, and information when possible on the individual from whom infection was acquired in order to obtain information on natural history. Subjects with acute and early HIV infection will be referred for enrollment into the proposed clinical trial, and for intensive immunologic and virologic studies as proposed, whether or not they elect to be treated. The Core will provide data management services for each of the participating projects; create methods for the rapid transmission of data to the Core, and establish, in conjunction with FSTRF, a common data base for the program project. This will facilitate analysis of associations between the observations collected by the collaborating investigators. Core staff will program the audio computer assisted interviewing system to be used for collection of demographic and behavioral information from cohort participants in English and French. The Core will assist in the development and review of new projects emerging from the program project and will provide biostatistical and epidemiological expertise for these proposals.

该核心将通过扩大和维护未感染男性和女性的高风险队列来支持此处提出的项目，开发一项外展计划，以招募急性或早期HIV感染的其他受试者，并在多个地点促进数据收集。该核心还将扩展NYU CFAR临床支持的功能 为所有项目提供生物统计学和流行病学分析的核心。核心将确定患有急性和早期艾滋病毒感染的人，以支持每个项目的及时完成。流行病学信息将在每个主题上累积，以估计艾滋病毒感染的日期和途径，人口特征和可能的信息，并在可能的个人中获得感染的个人，以获取有关自然历史的信息。患有急性和早期HIV感染的受试者将被转诊为拟议的临床试验，以及提出的强化免疫学和病毒学研究，无论是否选择接受治疗。核心将为每个参与项目提供数据管理服务；创建将数据快速传输到核心的方法，并与FSTRF一起建立程序项目的常见数据库。这将有助于分析合作调查人员收集的观察结果之间的关联。核心人员将编程音频计算机辅助面试 用于从同类参与者那里收集英语和法语的人群和行为信息的系统。核心将有助于开发和审查该计划项目的新项目，并将为这些建议提供生物统计学和流行病学专业知识。