EFFECT OF GENDER ON SUBSTRATE UTILIZATION DURING SUBMAXIMAL EXERCISE

性别对次极量运动期间基质利用的影响

• 批准号: 6276415
• 负责人: ANDREW R COGGAN
• 金额: $ 2.69万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276415
• 关键词: calorimetry; carbohydrate metabolism; catecholamines; chemical kinetics; clinical research; exercise; free fatty acids; gender difference; glucose; glycerol; hormone regulation /control mechanism; human subject; insulin; lipid metabolism; oxidation; physiologic stressor; radiotracer; stable isotope

The increase in studies focusing on aberrant metabolic conditions, i.e., diabetes, and those conditions which may cause metabolic alterations away from what has been described as normal, i.e., aging, necessitates the careful examination of gender differences in substrate utilization and hormone response to metabolic stress. It is therefore, the intent of this project to examine the gender differences in carbohydrate and lipid utilization during a prolonged submaximal exercise paradigm. Stable- isotopic tracers for glucose, free fatty acids, and glycerol will be used to determine substrate kinetics. In addition, substrate oxidation will be calculated from indirect calorimetry. Measurements of catecholamines, as well as insulin, will help to provide insight into any gender differences in substrate profiles which may develop during exercise. The findings from this project will add to the greater understanding of gender specific response to metabolic perturbation, and provide information to serve as a basis for using women in metabolic studies.

关注异常代谢条件的研究的增加，即 糖尿病以及可能导致代谢改变的疾病 从被描述为正常的东西，即衰老，需要 仔细检查底物利用率的性别差异和 激素对代谢应激的反应。 因此，这是一个意图 项目以检查碳水化合物和脂质的性别差异 长时间的次最大运动范式中的利用。 稳定的- 将使用用于葡萄糖，游离脂肪酸和甘油的同位素示踪剂 确定底物动力学。 另外，底物氧化将是 根据间接量热法计算。 儿茶酚胺的测量 以及胰岛素，将有助于洞悉任何性别差异 在运动过程中可能发展的底物概况中。 发现 从这个项目中，将增加对性别特定的更多理解 对代谢扰动的反应，并提供信息以作为 在代谢研究中使用女性的基础。