AMELIORATION OF HIV WASTING--EXERCISE AND MEGESTROL ACETATE

改善艾滋病毒消瘦——运动和醋酸甲地孕酮

• 批准号: 6275285
• 负责人: JAMIE H VON ROENN
• 金额: $ 2.26万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275285
• 关键词: AIDS; AIDS therapy; body composition; cachexia; clinical research; exercise; human subject; human therapy evaluation; outcomes research; pregnane compound; weight loss

Involuntary weight loss or wasting indicative of severe protein energy malnutri-tion is a frequent complication of AIDS. Since wasting associated with AIDS is characterized by a loss of muscle mass, and because the prognosis for patients with AIDS worsens with the loss of fat free mass, we hypothesize that a program of progressive resistance and aerobic exercise prescribed in combination with megestrol acetate will result in greater increases in lean body mass than either intervention alone for patients with AIDS-related weight loss.

非自愿体重减轻或浪费表示严重的蛋白质能量 营养不良是艾滋病的常见并发症。由于浪费相关 用艾滋病的特征是肌肉质量损失，并且因为 艾滋病患者的预后会随着无脂肪质量的损失而恶化，我们 假设渐进抗性和有氧运动的计划 与Mestrol乙酸酯结合规定将导致更大的 瘦体重的增加比仅对患者进行任何干预措施增加 与艾滋病相关的体重减轻。