THERAPEUTIC APPROACHES TO EXPERIMENTAL DEMENTIAS

实验性痴呆症的治疗方法

• 批准号: 6273894
• 负责人: laura MANUELIDIS
• 金额: $ 16.65万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6273894
• 关键词: adenylate cyclase; aging; amphotericin B; antiviral agents; brain cell; dementia; disease /disorder model; drug administration routes; electron microscopy; hamsters; histopathology; latent virus infection; membrane activity; model design /development; molecular pathology; nervous system infection; neurotropic virus; nonhuman therapy evaluation; pathologic process; prions; spongiform encephalopathy; synaptosomes; virus infection mechanism

We continue to evaluate in our animal models, selected drugs that may have therapeutic potential in CJD. Additionally, we will define by in vitro studies the molecular basis of CJD induced changes in membrane function (adenyl cyclase), and characterize the effects of pharmacologic agents which have the theoretical potential to reverse these effects.

我们继续在我们的动物模型中评估选定的药物 可能对克雅氏病具有治疗潜力。 此外，我们将 通过体外研究确定克雅氏病诱发的分子基础 膜功能（腺苷酸环化酶）的变化，并表征 具有理论作用的药物作用 扭转这些影响的潜力。