U OF MINNESOTA CHRC: MOLECULAR MODELS OF ORGANOGENESIS

明尼苏达大学 CHRC：器官发生的分子模型

• 批准号: 2609128
• 负责人: ALFRED F MICHAEL
• 金额: $ 35万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-15 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2609128
• 关键词: biomedical facility; career; child health care personnel; clinical research; developmental genetics; employment of women; genetic models; health science research; hematopoietic stem cells; high performance liquid chromatography; histogenesis; human subject; immunology; ion transport; minority health professional; model design /development; monoclonal antibody; pediatrics; physicians; tissue /cell culture; training; vertebrate embryology; biomedical facility; career; child health care personnel; clinical research; developmental genetics; employment of women; genetic models; health science research; hematopoietic stem cells; high performance liquid chromatography; histogenesis; human subject; immunology; ion transport; minority health professional; model design /development; monoclonal antibody; pediatrics; physicians; tissue /cell culture; training; vertebrate embryology

This application for a Child Health Research Center (CHRC) focuses on use of molecular models of organogenesis as a paradigm for the integration of pediatric science and developmental biology. The goals of the Center are three-fold: (l) to bring together a unique group of vigorous and well- funded established investigators whose expertise lies in the application of molecular and developmental models to the problems of organogenesis and pediatriC disease, (2) to integrate the CHRC into extant intra- departmental programs for faculty development and research training in the Department of Pediatrics and the Center for Developmental Biology, and (3) to enhance the recruitment of women and minorities to scientific careers in pediatrics. Toward this end, the program will recruit two young pediatric faculty each year who will be funded for two years, with the option for a competitive renewal in the third year. These New Project Development Funds will be allocated in the amount of $40,000 for the first year, $45,000 for the second year, and $60,000 for the third year, the latter to he derived as $30,000 from the CHRC and $30,000 from the Department of Pediatrics. Three modes of career development will be utilized: (l) defined individual daily mentorship by an established investigator of the CHRC, (2) formal training in the techniques of molecular and cellular developmental biology through a 12-day residential laboratory course with graduate students and basic science faculty at the University of Minnesota's Itasca Laboratories and (3) structured training sessions in the preparation of abstracts, oral presentations, and research grant applications and in the transition from mentee to independent investigator through the Pediatric Grants Resource Office. In order to attain these ends, the CHRC at the University of Minnesota is organized into three parts. The administrative core includes Alfred F. Michael, M.D. (P.I.) and Margaret K. Hostetter, M.D. (Program Director), who have daily responsibility for recruitment, supervision, and program development for Pediatric Scholars. Dr. Sharon Muret-Wagstaff (Recruitment Officer) will enhance the administrative core by applying her established skills in minority recruitment for the pediatric residency program to the goals of the CHRC. The laboratory core will be headed by Drs. Christopher Wylie and Janet Heasman (co-Directors of the Core Laboratory), both renowned developmental biologists who will oversee the performance of the Pediatric Scholars in the 12-day residential laboratory course and who will disburse supply funds. Because of the widespread dissemination of techniques in molecular and cellular biology throughout the Department of Pediatrics and the close cooperation of the established investigators in the program, a central research core facility and the money to equip it are not requested. The training program of the CHRC consists of 10 established investigators recruited from the Departments of Pediatrics, Medicine, Cell Biology and Neuroanatomy, Microbiology, Neurology, Laboratory Medicine, and Physiology for their vigorous laboratory programs and their enthusiasm for the training of young investigators. Together with the established investigators, the programmatic emphasis on organogenesis and pediatric disease will create for these Pediatric Scholars a superb laboratory-based environment that will enable them to produce and prosper as academic pediatric scientists.

该儿童健康研究中心（CHRC）的申请专注于使用 器官发生的分子模型作为整合的范式 小儿科学与发育生物学。中心的目标是 三倍：（l）汇集一群独特而充满活力的群体 资助的既定调查员，其专业知识在于申请 分子和发育模型的机器发生问题 小儿病，（2）将CHRC整合到现有的内部内 教师发展和研究培训的部门计划 儿科和发育生物学中心和（3） 为了增强妇女和少数群体从事科学职业的招聘 在儿科。为此，该计划将招募两个年轻人 每年都将获得两年资金的儿科教师 在第三年进行竞争性更新的选项。这些新项目 开发资金将分配给第一个40,000美元 一年，第二年为45,000美元，第三年为60,000美元， 后者从CHRC派往30,000美元，从 儿科系。职业发展的三种模式将是 利用：（l）由已建立的定义的个人每日指导 CHRC的研究者，（2）技术的正规培训 通过为期12天的住宅的分子和细胞发育生物学 与研究生和基础科学教师的实验室课程 明尼苏达大学的ITASCA实验室和（3）结构化培训 准备摘要，口头演示和研究的会议 授予申请以及从受训者到独立的过渡 通过小儿赠款资源办公室进行的调查员。 为了达到这些目的，明尼苏达大学的CHR是 分为三个部分。行政核心包括Alfred F. 迈克尔（P.I.）迈克尔（P.I.）和玛格丽特·K·Hostetter，医学博士（计划总监）， 每天负责招聘，监督和计划 小儿学者的发展。 Sharon Muret-Wagstaff博士（招聘 官员）将通过应用她的既定核心来增强行政核心 小儿居住计划的少数族裔招募技能 CHRC的目标。实验室核心将由博士领导。克里斯托弗 Wylie和Janet Heasman（核心实验室的联合指导者）都 著名的发展生物学家将监督 12天的住宅实验室课程中的儿科学者和谁 将拨出供应资金。由于广泛传播 整个部门的分子和细胞生物学技术 儿科和既定调查人员的密切合作 该计划，中央研究核心设施以及装备它的资金 不要求。 CHRC的培训计划包括10 已成立的调查人员从儿科部门招募， 医学，细胞生物学和神经解剖学，微生物学，神经病学， 实验室医学和生理学的实验室计划 以及他们对培训年轻调查人员的热情。 一起 与既定的调查人员一起，计划强调 这些小儿会创建器官发生和小儿疾病 学者是一个极好的基于实验室的环境，将使他们能够 作为学术儿科科学家产生和繁荣。